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Digoxin Plus Trametinib Therapy Achieves Disease Control in BRAF Wild-Type Metastatic Melanoma Patients

This is the first prospective study of a combination therapy involving a cardenolide and a MEK inhibitor for metastatic melanoma. Whereas BRAF mutant melanomas can exhibit profound responses to treatment with BRAF and MEK inhibitors, there are fewer options for BRAF wild-type melanomas. In preclinic...

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Detalles Bibliográficos
Autores principales:	Frankel, Arthur E., Eskiocak, Ugur, Gill, Jennifer G., Yuan, Stacy, Ramesh, Vijayashree, Froehlich, Thomas W., Ahn, Chul, Morrison, Sean J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2017
Materias:	Original article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342980/ https://www.ncbi.nlm.nih.gov/pubmed/28278423 http://dx.doi.org/10.1016/j.neo.2017.01.010

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