Cases of Impaired Oxidative Burst in HIV-Exposed Uninfected Infants’ Neutrophils—A Pilot Study

An increased risk of serious bacterial infections in HIV-exposed uninfected (HEU) infants has been demonstrated. Although neutrophils are essential for the protection of infants against bacterial infections, no study has investigated their profile in HEU infants to date. In this study, we assessed t...

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Autores principales: Maloupazoa Siawaya, Anicet Christel, Mveang-Nzoghe, Amandine, Mvoundza Ndjindji, Ofilia, Mintsa Ndong, Armel, Essone, Paulin N., Djoba Siawaya, Joel Fleury
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343014/
https://www.ncbi.nlm.nih.gov/pubmed/28337206
http://dx.doi.org/10.3389/fimmu.2017.00262
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author Maloupazoa Siawaya, Anicet Christel
Mveang-Nzoghe, Amandine
Mvoundza Ndjindji, Ofilia
Mintsa Ndong, Armel
Essone, Paulin N.
Djoba Siawaya, Joel Fleury
author_facet Maloupazoa Siawaya, Anicet Christel
Mveang-Nzoghe, Amandine
Mvoundza Ndjindji, Ofilia
Mintsa Ndong, Armel
Essone, Paulin N.
Djoba Siawaya, Joel Fleury
author_sort Maloupazoa Siawaya, Anicet Christel
collection PubMed
description An increased risk of serious bacterial infections in HIV-exposed uninfected (HEU) infants has been demonstrated. Although neutrophils are essential for the protection of infants against bacterial infections, no study has investigated their profile in HEU infants to date. In this study, we assessed the function of neutrophils in HEU infants using the nitroblue tetrazolium reduction test. Among 25 HEU infants, 9 (36%) showed a reduced ability of their neutrophils to produce reactive oxygen species upon stimulation with bacteria. No alteration of total neutrophil counts was noted in the blood of HEU infants indicating that the alteration observed in the 36% of HEU infants may only be functional. Conclusively, impaired neutrophil function could be a factor of vulnerability in HEU infants.
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spelling pubmed-53430142017-03-23 Cases of Impaired Oxidative Burst in HIV-Exposed Uninfected Infants’ Neutrophils—A Pilot Study Maloupazoa Siawaya, Anicet Christel Mveang-Nzoghe, Amandine Mvoundza Ndjindji, Ofilia Mintsa Ndong, Armel Essone, Paulin N. Djoba Siawaya, Joel Fleury Front Immunol Immunology An increased risk of serious bacterial infections in HIV-exposed uninfected (HEU) infants has been demonstrated. Although neutrophils are essential for the protection of infants against bacterial infections, no study has investigated their profile in HEU infants to date. In this study, we assessed the function of neutrophils in HEU infants using the nitroblue tetrazolium reduction test. Among 25 HEU infants, 9 (36%) showed a reduced ability of their neutrophils to produce reactive oxygen species upon stimulation with bacteria. No alteration of total neutrophil counts was noted in the blood of HEU infants indicating that the alteration observed in the 36% of HEU infants may only be functional. Conclusively, impaired neutrophil function could be a factor of vulnerability in HEU infants. Frontiers Media S.A. 2017-03-09 /pmc/articles/PMC5343014/ /pubmed/28337206 http://dx.doi.org/10.3389/fimmu.2017.00262 Text en Copyright © 2017 Maloupazoa Siawaya, Mveang-Nzoghe, Mvoundza Ndjindji, Mintsa Ndong, Essone and Djoba Siawaya. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Maloupazoa Siawaya, Anicet Christel
Mveang-Nzoghe, Amandine
Mvoundza Ndjindji, Ofilia
Mintsa Ndong, Armel
Essone, Paulin N.
Djoba Siawaya, Joel Fleury
Cases of Impaired Oxidative Burst in HIV-Exposed Uninfected Infants’ Neutrophils—A Pilot Study
title Cases of Impaired Oxidative Burst in HIV-Exposed Uninfected Infants’ Neutrophils—A Pilot Study
title_full Cases of Impaired Oxidative Burst in HIV-Exposed Uninfected Infants’ Neutrophils—A Pilot Study
title_fullStr Cases of Impaired Oxidative Burst in HIV-Exposed Uninfected Infants’ Neutrophils—A Pilot Study
title_full_unstemmed Cases of Impaired Oxidative Burst in HIV-Exposed Uninfected Infants’ Neutrophils—A Pilot Study
title_short Cases of Impaired Oxidative Burst in HIV-Exposed Uninfected Infants’ Neutrophils—A Pilot Study
title_sort cases of impaired oxidative burst in hiv-exposed uninfected infants’ neutrophils—a pilot study
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343014/
https://www.ncbi.nlm.nih.gov/pubmed/28337206
http://dx.doi.org/10.3389/fimmu.2017.00262
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