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Aromatic compounds from an aqueous extract of “ban lan gen” and their antiviral activities
A pair of new diphenyl glycerol ether enantiomers (−)-1 and (+)-1 and two new methyl benzamidobenzoates 2 and 3, named (−)-(R)- and (+)-(S)-isatindigotrioic acid [(−)-1 and (+)-1] and isatindigoticamides A (2) and B (3), respectively, were isolated from an aqueous decoction of the roots of Isatis in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343108/ https://www.ncbi.nlm.nih.gov/pubmed/28303224 http://dx.doi.org/10.1016/j.apsb.2016.09.004 |
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author | Liu, Yufeng Chen, Minghua Guo, Qinglan Li, Yuhuan Jiang, Jiandong Shi, Jiangong |
author_facet | Liu, Yufeng Chen, Minghua Guo, Qinglan Li, Yuhuan Jiang, Jiandong Shi, Jiangong |
author_sort | Liu, Yufeng |
collection | PubMed |
description | A pair of new diphenyl glycerol ether enantiomers (−)-1 and (+)-1 and two new methyl benzamidobenzoates 2 and 3, named (−)-(R)- and (+)-(S)-isatindigotrioic acid [(−)-1 and (+)-1] and isatindigoticamides A (2) and B (3), respectively, were isolated from an aqueous decoction of the roots of Isatis indigotica (ban lan gen). Their structures were elucidated by spectroscopic data analysis including 2D NMR experiments. The absolute configurations of (−)-1 and (+)-1 were assigned based on the CD exciton chirality method. Compounds 2 and 3 exhibited antiviral activities against HSV-1 with IC(50) values of 4.87 and 25.87 μmol/L, respectively. Compound 2 was also found active against Coxsackie virus B3 and LPS-induced NO production. |
format | Online Article Text |
id | pubmed-5343108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-53431082017-03-16 Aromatic compounds from an aqueous extract of “ban lan gen” and their antiviral activities Liu, Yufeng Chen, Minghua Guo, Qinglan Li, Yuhuan Jiang, Jiandong Shi, Jiangong Acta Pharm Sin B Original Article A pair of new diphenyl glycerol ether enantiomers (−)-1 and (+)-1 and two new methyl benzamidobenzoates 2 and 3, named (−)-(R)- and (+)-(S)-isatindigotrioic acid [(−)-1 and (+)-1] and isatindigoticamides A (2) and B (3), respectively, were isolated from an aqueous decoction of the roots of Isatis indigotica (ban lan gen). Their structures were elucidated by spectroscopic data analysis including 2D NMR experiments. The absolute configurations of (−)-1 and (+)-1 were assigned based on the CD exciton chirality method. Compounds 2 and 3 exhibited antiviral activities against HSV-1 with IC(50) values of 4.87 and 25.87 μmol/L, respectively. Compound 2 was also found active against Coxsackie virus B3 and LPS-induced NO production. Elsevier 2017-03 2016-11-08 /pmc/articles/PMC5343108/ /pubmed/28303224 http://dx.doi.org/10.1016/j.apsb.2016.09.004 Text en © 2017 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Liu, Yufeng Chen, Minghua Guo, Qinglan Li, Yuhuan Jiang, Jiandong Shi, Jiangong Aromatic compounds from an aqueous extract of “ban lan gen” and their antiviral activities |
title | Aromatic compounds from an aqueous extract of “ban lan gen” and their antiviral activities |
title_full | Aromatic compounds from an aqueous extract of “ban lan gen” and their antiviral activities |
title_fullStr | Aromatic compounds from an aqueous extract of “ban lan gen” and their antiviral activities |
title_full_unstemmed | Aromatic compounds from an aqueous extract of “ban lan gen” and their antiviral activities |
title_short | Aromatic compounds from an aqueous extract of “ban lan gen” and their antiviral activities |
title_sort | aromatic compounds from an aqueous extract of “ban lan gen” and their antiviral activities |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343108/ https://www.ncbi.nlm.nih.gov/pubmed/28303224 http://dx.doi.org/10.1016/j.apsb.2016.09.004 |
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