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The modification of natural products for medical use
Drug innovation is characterized by painstaking molecular-level syntheses and modifications as the basic components of research and development. Similarly, natural products are chemically tailored and modified based upon their structural and biological properties. To some extent, the modification of...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343118/ https://www.ncbi.nlm.nih.gov/pubmed/28303218 http://dx.doi.org/10.1016/j.apsb.2016.06.003 |
| _version_ | 1782513309967187968 |
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| author | Guo, Zongru |
| author_facet | Guo, Zongru |
| author_sort | Guo, Zongru |
| collection | PubMed |
| description | Drug innovation is characterized by painstaking molecular-level syntheses and modifications as the basic components of research and development. Similarly, natural products are chemically tailored and modified based upon their structural and biological properties. To some extent, the modification of natural products is quite different from de novo structure-based drug discovery. This review describes the general strategies and principles for the modification of natural products to drugs, as illustrated by several successful medicines that originated from natural products. |
| format | Online Article Text |
| id | pubmed-5343118 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-53431182017-03-16 The modification of natural products for medical use Guo, Zongru Acta Pharm Sin B Review Drug innovation is characterized by painstaking molecular-level syntheses and modifications as the basic components of research and development. Similarly, natural products are chemically tailored and modified based upon their structural and biological properties. To some extent, the modification of natural products is quite different from de novo structure-based drug discovery. This review describes the general strategies and principles for the modification of natural products to drugs, as illustrated by several successful medicines that originated from natural products. Elsevier 2017-03 2016-11-25 /pmc/articles/PMC5343118/ /pubmed/28303218 http://dx.doi.org/10.1016/j.apsb.2016.06.003 Text en © 2017 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Review Guo, Zongru The modification of natural products for medical use |
| title | The modification of natural products for medical use |
| title_full | The modification of natural products for medical use |
| title_fullStr | The modification of natural products for medical use |
| title_full_unstemmed | The modification of natural products for medical use |
| title_short | The modification of natural products for medical use |
| title_sort | modification of natural products for medical use |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343118/ https://www.ncbi.nlm.nih.gov/pubmed/28303218 http://dx.doi.org/10.1016/j.apsb.2016.06.003 |
| work_keys_str_mv | AT guozongru themodificationofnaturalproductsformedicaluse AT guozongru modificationofnaturalproductsformedicaluse |