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Successful treatment of recurrent Helicobacter fennelliae bacteraemia by selective digestive decontamination with kanamycin in a lung cancer patient receiving chemotherapy

INTRODUCTION: Helicobacter fennelliae is an enterohepatic Helicobacter species causing bacteraemia in immunocompromised hosts. Only a few cases of recurrent H. fennelliae bacteraemia have been reported in Japan and there are no guidelines regarding antimicrobial treatment for H. fennelliae infection...

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Autores principales: Fujiya, Yoshihiro, Nagamatsu, Maki, Tomida, Junko, Kawamura, Yoshiaki, Yamamoto, Kei, Mawatari, Momoko, Kutsuna, Satoshi, Takeshita, Nozomi, Hayakawa, Kayoko, Kanagawa, Shuzo, Mezaki, Kazuhisa, Hashimoto, Masao, Ishii, Satoru, Ohmagari, Norio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343149/
https://www.ncbi.nlm.nih.gov/pubmed/28348791
http://dx.doi.org/10.1099/jmmcr.0.005069
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author Fujiya, Yoshihiro
Nagamatsu, Maki
Tomida, Junko
Kawamura, Yoshiaki
Yamamoto, Kei
Mawatari, Momoko
Kutsuna, Satoshi
Takeshita, Nozomi
Hayakawa, Kayoko
Kanagawa, Shuzo
Mezaki, Kazuhisa
Hashimoto, Masao
Ishii, Satoru
Ohmagari, Norio
author_facet Fujiya, Yoshihiro
Nagamatsu, Maki
Tomida, Junko
Kawamura, Yoshiaki
Yamamoto, Kei
Mawatari, Momoko
Kutsuna, Satoshi
Takeshita, Nozomi
Hayakawa, Kayoko
Kanagawa, Shuzo
Mezaki, Kazuhisa
Hashimoto, Masao
Ishii, Satoru
Ohmagari, Norio
author_sort Fujiya, Yoshihiro
collection PubMed
description INTRODUCTION: Helicobacter fennelliae is an enterohepatic Helicobacter species causing bacteraemia in immunocompromised hosts. Only a few cases of recurrent H. fennelliae bacteraemia have been reported in Japan and there are no guidelines regarding antimicrobial treatment for H. fennelliae infection. CASE PRESENTATION: H. fennelliae bacteraemia was observed in a patient receiving platinum-based chemotherapy for lung cancer. To prevent recurrence, the patient received antibiotic therapy with cefepime, amoxicillin and doxycycline for 6 weeks, which is similar to the therapy for Helicobacter cinaedi bacteraemia. Bacteraemia recurred despite the long-term antibiotic therapy. We hypothesized that the H. fennelliae bacteraemia originated from endogenous infection in the intestinal tract due to the long-term damage of the enteric mucosa by platinum-based drugs and performed selective digestive decontamination (SDD) with kanamycin. Bacteraemia did not recur after SDD. CONCLUSION: Our observations indicate that clinicians should be aware of possible recurrent H. fennelliae bacteraemia, which could be effectively prevented by SDD with kanamycin.
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spelling pubmed-53431492017-03-27 Successful treatment of recurrent Helicobacter fennelliae bacteraemia by selective digestive decontamination with kanamycin in a lung cancer patient receiving chemotherapy Fujiya, Yoshihiro Nagamatsu, Maki Tomida, Junko Kawamura, Yoshiaki Yamamoto, Kei Mawatari, Momoko Kutsuna, Satoshi Takeshita, Nozomi Hayakawa, Kayoko Kanagawa, Shuzo Mezaki, Kazuhisa Hashimoto, Masao Ishii, Satoru Ohmagari, Norio JMM Case Rep Case Report INTRODUCTION: Helicobacter fennelliae is an enterohepatic Helicobacter species causing bacteraemia in immunocompromised hosts. Only a few cases of recurrent H. fennelliae bacteraemia have been reported in Japan and there are no guidelines regarding antimicrobial treatment for H. fennelliae infection. CASE PRESENTATION: H. fennelliae bacteraemia was observed in a patient receiving platinum-based chemotherapy for lung cancer. To prevent recurrence, the patient received antibiotic therapy with cefepime, amoxicillin and doxycycline for 6 weeks, which is similar to the therapy for Helicobacter cinaedi bacteraemia. Bacteraemia recurred despite the long-term antibiotic therapy. We hypothesized that the H. fennelliae bacteraemia originated from endogenous infection in the intestinal tract due to the long-term damage of the enteric mucosa by platinum-based drugs and performed selective digestive decontamination (SDD) with kanamycin. Bacteraemia did not recur after SDD. CONCLUSION: Our observations indicate that clinicians should be aware of possible recurrent H. fennelliae bacteraemia, which could be effectively prevented by SDD with kanamycin. Microbiology Society 2016-10-31 /pmc/articles/PMC5343149/ /pubmed/28348791 http://dx.doi.org/10.1099/jmmcr.0.005069 Text en 2016 The Authors. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
spellingShingle Case Report
Fujiya, Yoshihiro
Nagamatsu, Maki
Tomida, Junko
Kawamura, Yoshiaki
Yamamoto, Kei
Mawatari, Momoko
Kutsuna, Satoshi
Takeshita, Nozomi
Hayakawa, Kayoko
Kanagawa, Shuzo
Mezaki, Kazuhisa
Hashimoto, Masao
Ishii, Satoru
Ohmagari, Norio
Successful treatment of recurrent Helicobacter fennelliae bacteraemia by selective digestive decontamination with kanamycin in a lung cancer patient receiving chemotherapy
title Successful treatment of recurrent Helicobacter fennelliae bacteraemia by selective digestive decontamination with kanamycin in a lung cancer patient receiving chemotherapy
title_full Successful treatment of recurrent Helicobacter fennelliae bacteraemia by selective digestive decontamination with kanamycin in a lung cancer patient receiving chemotherapy
title_fullStr Successful treatment of recurrent Helicobacter fennelliae bacteraemia by selective digestive decontamination with kanamycin in a lung cancer patient receiving chemotherapy
title_full_unstemmed Successful treatment of recurrent Helicobacter fennelliae bacteraemia by selective digestive decontamination with kanamycin in a lung cancer patient receiving chemotherapy
title_short Successful treatment of recurrent Helicobacter fennelliae bacteraemia by selective digestive decontamination with kanamycin in a lung cancer patient receiving chemotherapy
title_sort successful treatment of recurrent helicobacter fennelliae bacteraemia by selective digestive decontamination with kanamycin in a lung cancer patient receiving chemotherapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343149/
https://www.ncbi.nlm.nih.gov/pubmed/28348791
http://dx.doi.org/10.1099/jmmcr.0.005069
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