YCl(3) Promotes Neuronal Cell Death by Inducing Apoptotic Pathways in Rats

The pollutants rare earth elements (REEs) have posed great threats to human health. To investigate the cytotoxicity of yttrium (Y), a model that rats have free access to water containing YCl(3) for 6 months is utilized. The results showed that YCl(3) treatment promoted neuronal cell apoptosis by upr...

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Detalles Bibliográficos
Autores principales: Ding, Yechun, Tian, Yuantong, Zeng, Zhaoyi, Shuai, Ping, Lan, Haiying, Zhu, Xianshen, Zhong, Yi, Wu, Longhuo, Fan, Xiaona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343218/
https://www.ncbi.nlm.nih.gov/pubmed/28326317
http://dx.doi.org/10.1155/2017/2183658
Descripción
Sumario:The pollutants rare earth elements (REEs) have posed great threats to human health. To investigate the cytotoxicity of yttrium (Y), a model that rats have free access to water containing YCl(3) for 6 months is utilized. The results showed that YCl(3) treatment promoted neuronal cell apoptosis by upregulating the proapoptotic factors Bax, caspase-3, Cyto c, and DAPK and by downregulating the antiapoptotic factors Bcl-2 and XIAP at both mRNA and protein levels. Conclusively, YCl(3) exhibited cytotoxicity and promoted neuronal cell death by the induction of apoptotic pathways.

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