YCl(3) Promotes Neuronal Cell Death by Inducing Apoptotic Pathways in Rats

The pollutants rare earth elements (REEs) have posed great threats to human health. To investigate the cytotoxicity of yttrium (Y), a model that rats have free access to water containing YCl(3) for 6 months is utilized. The results showed that YCl(3) treatment promoted neuronal cell apoptosis by upr...

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Autores principales: Ding, Yechun, Tian, Yuantong, Zeng, Zhaoyi, Shuai, Ping, Lan, Haiying, Zhu, Xianshen, Zhong, Yi, Wu, Longhuo, Fan, Xiaona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343218/
https://www.ncbi.nlm.nih.gov/pubmed/28326317
http://dx.doi.org/10.1155/2017/2183658
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author Ding, Yechun
Tian, Yuantong
Zeng, Zhaoyi
Shuai, Ping
Lan, Haiying
Zhu, Xianshen
Zhong, Yi
Wu, Longhuo
Fan, Xiaona
author_facet Ding, Yechun
Tian, Yuantong
Zeng, Zhaoyi
Shuai, Ping
Lan, Haiying
Zhu, Xianshen
Zhong, Yi
Wu, Longhuo
Fan, Xiaona
author_sort Ding, Yechun
collection PubMed
description The pollutants rare earth elements (REEs) have posed great threats to human health. To investigate the cytotoxicity of yttrium (Y), a model that rats have free access to water containing YCl(3) for 6 months is utilized. The results showed that YCl(3) treatment promoted neuronal cell apoptosis by upregulating the proapoptotic factors Bax, caspase-3, Cyto c, and DAPK and by downregulating the antiapoptotic factors Bcl-2 and XIAP at both mRNA and protein levels. Conclusively, YCl(3) exhibited cytotoxicity and promoted neuronal cell death by the induction of apoptotic pathways.
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spelling pubmed-53432182017-03-21 YCl(3) Promotes Neuronal Cell Death by Inducing Apoptotic Pathways in Rats Ding, Yechun Tian, Yuantong Zeng, Zhaoyi Shuai, Ping Lan, Haiying Zhu, Xianshen Zhong, Yi Wu, Longhuo Fan, Xiaona Biomed Res Int Research Article The pollutants rare earth elements (REEs) have posed great threats to human health. To investigate the cytotoxicity of yttrium (Y), a model that rats have free access to water containing YCl(3) for 6 months is utilized. The results showed that YCl(3) treatment promoted neuronal cell apoptosis by upregulating the proapoptotic factors Bax, caspase-3, Cyto c, and DAPK and by downregulating the antiapoptotic factors Bcl-2 and XIAP at both mRNA and protein levels. Conclusively, YCl(3) exhibited cytotoxicity and promoted neuronal cell death by the induction of apoptotic pathways. Hindawi Publishing Corporation 2017 2017-02-23 /pmc/articles/PMC5343218/ /pubmed/28326317 http://dx.doi.org/10.1155/2017/2183658 Text en Copyright © 2017 Yechun Ding et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ding, Yechun
Tian, Yuantong
Zeng, Zhaoyi
Shuai, Ping
Lan, Haiying
Zhu, Xianshen
Zhong, Yi
Wu, Longhuo
Fan, Xiaona
YCl(3) Promotes Neuronal Cell Death by Inducing Apoptotic Pathways in Rats
title YCl(3) Promotes Neuronal Cell Death by Inducing Apoptotic Pathways in Rats
title_full YCl(3) Promotes Neuronal Cell Death by Inducing Apoptotic Pathways in Rats
title_fullStr YCl(3) Promotes Neuronal Cell Death by Inducing Apoptotic Pathways in Rats
title_full_unstemmed YCl(3) Promotes Neuronal Cell Death by Inducing Apoptotic Pathways in Rats
title_short YCl(3) Promotes Neuronal Cell Death by Inducing Apoptotic Pathways in Rats
title_sort ycl(3) promotes neuronal cell death by inducing apoptotic pathways in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343218/
https://www.ncbi.nlm.nih.gov/pubmed/28326317
http://dx.doi.org/10.1155/2017/2183658
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