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An Unusual Clinical Presentation of Solitary Fibrous Tumor in the Oral Cavity
Solitary fibrous tumor is a rare neoplasm of mesenchymal origin that usually affects the pleura. This rarity becomes more relevant in the oral cavity since the clinical features are nonspecific. A 66-year-old female patient presented with a 3-month history of a swelling in the floor of the mouth, me...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343232/ https://www.ncbi.nlm.nih.gov/pubmed/28326216 http://dx.doi.org/10.1155/2017/4395049 |
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author | de Morais, Everton Freitas Moreira, Deborah Gondim Lambert Oliveira, Viviane Alves De Rodrigues, Rodrigo Rodrigues Germano, Adriano Rocha Freitas, Roseana de Almeida |
author_facet | de Morais, Everton Freitas Moreira, Deborah Gondim Lambert Oliveira, Viviane Alves De Rodrigues, Rodrigo Rodrigues Germano, Adriano Rocha Freitas, Roseana de Almeida |
author_sort | de Morais, Everton Freitas |
collection | PubMed |
description | Solitary fibrous tumor is a rare neoplasm of mesenchymal origin that usually affects the pleura. This rarity becomes more relevant in the oral cavity since the clinical features are nonspecific. A 66-year-old female patient presented with a 3-month history of a swelling in the floor of the mouth, measuring 2 cm in greatest diameter, and pain symptomatology. Occlusal and panoramic radiographs showed no bone involvement. Ultrasonography of the submandibular and parotid salivary glands revealed normal morphology, dimensions, and echogenicity. During this exam, a nodular image of low echogenicity measuring about 2.7 × 1.8 cm was detected. An excisional biopsy was performed and histopathological analysis revealed a well-defined tumor-like lesion with alternation between hypercellular areas without a defined pattern and hypocellular areas. On immunohistochemistry, the tumor was positive for CD34 and CD99 and negative for α-SMA, S-100, and bcl-2. Combining the histopathological and immunohistochemical features, the diagnosis was solitary fibrous tumor. The patient is under periodical clinical follow-up and shows no signs of recurrence 7 months after surgical excision of the tumor. The combination of clinical-pathological and immunohistochemical features is necessary for the diagnosis. |
format | Online Article Text |
id | pubmed-5343232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-53432322017-03-21 An Unusual Clinical Presentation of Solitary Fibrous Tumor in the Oral Cavity de Morais, Everton Freitas Moreira, Deborah Gondim Lambert Oliveira, Viviane Alves De Rodrigues, Rodrigo Rodrigues Germano, Adriano Rocha Freitas, Roseana de Almeida Case Rep Pathol Case Report Solitary fibrous tumor is a rare neoplasm of mesenchymal origin that usually affects the pleura. This rarity becomes more relevant in the oral cavity since the clinical features are nonspecific. A 66-year-old female patient presented with a 3-month history of a swelling in the floor of the mouth, measuring 2 cm in greatest diameter, and pain symptomatology. Occlusal and panoramic radiographs showed no bone involvement. Ultrasonography of the submandibular and parotid salivary glands revealed normal morphology, dimensions, and echogenicity. During this exam, a nodular image of low echogenicity measuring about 2.7 × 1.8 cm was detected. An excisional biopsy was performed and histopathological analysis revealed a well-defined tumor-like lesion with alternation between hypercellular areas without a defined pattern and hypocellular areas. On immunohistochemistry, the tumor was positive for CD34 and CD99 and negative for α-SMA, S-100, and bcl-2. Combining the histopathological and immunohistochemical features, the diagnosis was solitary fibrous tumor. The patient is under periodical clinical follow-up and shows no signs of recurrence 7 months after surgical excision of the tumor. The combination of clinical-pathological and immunohistochemical features is necessary for the diagnosis. Hindawi Publishing Corporation 2017 2017-02-23 /pmc/articles/PMC5343232/ /pubmed/28326216 http://dx.doi.org/10.1155/2017/4395049 Text en Copyright © 2017 Everton Freitas de Morais et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report de Morais, Everton Freitas Moreira, Deborah Gondim Lambert Oliveira, Viviane Alves De Rodrigues, Rodrigo Rodrigues Germano, Adriano Rocha Freitas, Roseana de Almeida An Unusual Clinical Presentation of Solitary Fibrous Tumor in the Oral Cavity |
title | An Unusual Clinical Presentation of Solitary Fibrous Tumor in the Oral Cavity |
title_full | An Unusual Clinical Presentation of Solitary Fibrous Tumor in the Oral Cavity |
title_fullStr | An Unusual Clinical Presentation of Solitary Fibrous Tumor in the Oral Cavity |
title_full_unstemmed | An Unusual Clinical Presentation of Solitary Fibrous Tumor in the Oral Cavity |
title_short | An Unusual Clinical Presentation of Solitary Fibrous Tumor in the Oral Cavity |
title_sort | unusual clinical presentation of solitary fibrous tumor in the oral cavity |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343232/ https://www.ncbi.nlm.nih.gov/pubmed/28326216 http://dx.doi.org/10.1155/2017/4395049 |
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