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Long-Term Intake of Uncaria rhynchophylla Reduces S100B and RAGE Protein Levels in Kainic Acid-Induced Epileptic Seizures Rats

Epileptic seizures are crucial clinical manifestations of recurrent neuronal discharges in the brain. An imbalance between the excitatory and inhibitory neuronal discharges causes brain damage and cell loss. Herbal medicines offer alternative treatment options for epilepsy because of their low cost...

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Autores principales: Tang, Nou-Ying, Lin, Yi-Wen, Ho, Tin-Yun, Cheng, Chin-Yi, Chen, Chao-Hsiang, Hsieh, Ching-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343263/
https://www.ncbi.nlm.nih.gov/pubmed/28386293
http://dx.doi.org/10.1155/2017/9732854
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author Tang, Nou-Ying
Lin, Yi-Wen
Ho, Tin-Yun
Cheng, Chin-Yi
Chen, Chao-Hsiang
Hsieh, Ching-Liang
author_facet Tang, Nou-Ying
Lin, Yi-Wen
Ho, Tin-Yun
Cheng, Chin-Yi
Chen, Chao-Hsiang
Hsieh, Ching-Liang
author_sort Tang, Nou-Ying
collection PubMed
description Epileptic seizures are crucial clinical manifestations of recurrent neuronal discharges in the brain. An imbalance between the excitatory and inhibitory neuronal discharges causes brain damage and cell loss. Herbal medicines offer alternative treatment options for epilepsy because of their low cost and few side effects. We established a rat epilepsy model by injecting kainic acid (KA, 12 mg/kg, i.p.) and subsequently investigated the effect of Uncaria rhynchophylla (UR) and its underlying mechanisms. Electroencephalogram and epileptic behaviors revealed that the KA injection induced epileptic seizures. Following KA injection, S100B levels increased in the hippocampus. This phenomenon was attenuated by the oral administration of UR and valproic acid (VA, 250 mg/kg). Both drugs significantly reversed receptor potentiation for advanced glycation end product proteins. Rats with KA-induced epilepsy exhibited no increase in the expression of metabotropic glutamate receptor 3, monocyte chemoattractant protein 1, and chemokine receptor type 2, which play a role in inflammation. Our results provide novel and detailed mechanisms, explaining the role of UR in KA-induced epileptic seizures in hippocampal CA1 neurons.
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spelling pubmed-53432632017-04-06 Long-Term Intake of Uncaria rhynchophylla Reduces S100B and RAGE Protein Levels in Kainic Acid-Induced Epileptic Seizures Rats Tang, Nou-Ying Lin, Yi-Wen Ho, Tin-Yun Cheng, Chin-Yi Chen, Chao-Hsiang Hsieh, Ching-Liang Evid Based Complement Alternat Med Research Article Epileptic seizures are crucial clinical manifestations of recurrent neuronal discharges in the brain. An imbalance between the excitatory and inhibitory neuronal discharges causes brain damage and cell loss. Herbal medicines offer alternative treatment options for epilepsy because of their low cost and few side effects. We established a rat epilepsy model by injecting kainic acid (KA, 12 mg/kg, i.p.) and subsequently investigated the effect of Uncaria rhynchophylla (UR) and its underlying mechanisms. Electroencephalogram and epileptic behaviors revealed that the KA injection induced epileptic seizures. Following KA injection, S100B levels increased in the hippocampus. This phenomenon was attenuated by the oral administration of UR and valproic acid (VA, 250 mg/kg). Both drugs significantly reversed receptor potentiation for advanced glycation end product proteins. Rats with KA-induced epilepsy exhibited no increase in the expression of metabotropic glutamate receptor 3, monocyte chemoattractant protein 1, and chemokine receptor type 2, which play a role in inflammation. Our results provide novel and detailed mechanisms, explaining the role of UR in KA-induced epileptic seizures in hippocampal CA1 neurons. Hindawi Publishing Corporation 2017 2017-02-23 /pmc/articles/PMC5343263/ /pubmed/28386293 http://dx.doi.org/10.1155/2017/9732854 Text en Copyright © 2017 Nou-Ying Tang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tang, Nou-Ying
Lin, Yi-Wen
Ho, Tin-Yun
Cheng, Chin-Yi
Chen, Chao-Hsiang
Hsieh, Ching-Liang
Long-Term Intake of Uncaria rhynchophylla Reduces S100B and RAGE Protein Levels in Kainic Acid-Induced Epileptic Seizures Rats
title Long-Term Intake of Uncaria rhynchophylla Reduces S100B and RAGE Protein Levels in Kainic Acid-Induced Epileptic Seizures Rats
title_full Long-Term Intake of Uncaria rhynchophylla Reduces S100B and RAGE Protein Levels in Kainic Acid-Induced Epileptic Seizures Rats
title_fullStr Long-Term Intake of Uncaria rhynchophylla Reduces S100B and RAGE Protein Levels in Kainic Acid-Induced Epileptic Seizures Rats
title_full_unstemmed Long-Term Intake of Uncaria rhynchophylla Reduces S100B and RAGE Protein Levels in Kainic Acid-Induced Epileptic Seizures Rats
title_short Long-Term Intake of Uncaria rhynchophylla Reduces S100B and RAGE Protein Levels in Kainic Acid-Induced Epileptic Seizures Rats
title_sort long-term intake of uncaria rhynchophylla reduces s100b and rage protein levels in kainic acid-induced epileptic seizures rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343263/
https://www.ncbi.nlm.nih.gov/pubmed/28386293
http://dx.doi.org/10.1155/2017/9732854
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