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An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity

Alpha-1 adrenergic receptors (α1-ARs) play adaptive and protective roles in the heart. Dabuzalgron is an oral selective α1A-AR agonist that was well tolerated in multiple clinical trials of treatment for urinary incontinence, but has never been used to treat heart disease in humans or animal models....

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Detalles Bibliográficos
Autores principales:	Beak, Ju Youn, Huang, Wei, Parker, Joel S., Hicks, Sean T., Patterson, Cam, Simpson, Paul C., Ma, Anqi, Jin, Jian, Jensen, Brian C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	PRECLINICAL RESEARCH
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343290/ https://www.ncbi.nlm.nih.gov/pubmed/28286875 http://dx.doi.org/10.1016/j.jacbts.2016.10.006

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