Effect of microbial siderophores on mammalian non-malignant and malignant cell lines

BACKGROUND: Iron is a vital nutrient for all cells, and malignant cells have a higher requirement for the metal due to their rapid multiplication. Bacterial siderophores can be used to reduce free ferric ion concentration from the cellular environment. METHODS: In the present study, we have evaluate...

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Detalles Bibliográficos
Autores principales: Gokarn, Karuna, Sarangdhar, Vishwas, Pal, Ramprasad B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343307/
https://www.ncbi.nlm.nih.gov/pubmed/28274224
http://dx.doi.org/10.1186/s12906-017-1657-8
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author Gokarn, Karuna
Sarangdhar, Vishwas
Pal, Ramprasad B.
author_facet Gokarn, Karuna
Sarangdhar, Vishwas
Pal, Ramprasad B.
author_sort Gokarn, Karuna
collection PubMed
description BACKGROUND: Iron is a vital nutrient for all cells, and malignant cells have a higher requirement for the metal due to their rapid multiplication. Bacterial siderophores can be used to reduce free ferric ion concentration from the cellular environment. METHODS: In the present study, we have evaluated effect of three siderophores – exochelin-MS, mycobactin S and deferoxamine B on the proliferation of mammalian cell lines using MTT assay. RESULTS: These siderophores caused a significant decrease in the viability of malignant cells, without significantly affecting non-malignant cells. CONCLUSIONS: Based on these results, we suggest that iron-chelation therapy could be explored as an adjunctive therapeutic option against cancer along with other therapies.
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spelling pubmed-53433072017-03-10 Effect of microbial siderophores on mammalian non-malignant and malignant cell lines Gokarn, Karuna Sarangdhar, Vishwas Pal, Ramprasad B. BMC Complement Altern Med Research Article BACKGROUND: Iron is a vital nutrient for all cells, and malignant cells have a higher requirement for the metal due to their rapid multiplication. Bacterial siderophores can be used to reduce free ferric ion concentration from the cellular environment. METHODS: In the present study, we have evaluated effect of three siderophores – exochelin-MS, mycobactin S and deferoxamine B on the proliferation of mammalian cell lines using MTT assay. RESULTS: These siderophores caused a significant decrease in the viability of malignant cells, without significantly affecting non-malignant cells. CONCLUSIONS: Based on these results, we suggest that iron-chelation therapy could be explored as an adjunctive therapeutic option against cancer along with other therapies. BioMed Central 2017-03-09 /pmc/articles/PMC5343307/ /pubmed/28274224 http://dx.doi.org/10.1186/s12906-017-1657-8 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Gokarn, Karuna
Sarangdhar, Vishwas
Pal, Ramprasad B.
Effect of microbial siderophores on mammalian non-malignant and malignant cell lines
title Effect of microbial siderophores on mammalian non-malignant and malignant cell lines
title_full Effect of microbial siderophores on mammalian non-malignant and malignant cell lines
title_fullStr Effect of microbial siderophores on mammalian non-malignant and malignant cell lines
title_full_unstemmed Effect of microbial siderophores on mammalian non-malignant and malignant cell lines
title_short Effect of microbial siderophores on mammalian non-malignant and malignant cell lines
title_sort effect of microbial siderophores on mammalian non-malignant and malignant cell lines
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343307/
https://www.ncbi.nlm.nih.gov/pubmed/28274224
http://dx.doi.org/10.1186/s12906-017-1657-8
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