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Topical tacrolimus in anterior segment inflammatory disorders
Immune mediated inflammatory anterior segment diseases are variable and their management requires intense immunosuppression. Treatment with topical steroids is associated with serious ocular side effects. In order to overcome the potentially blinding complications of topical steroids, immunomodulato...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343311/ https://www.ncbi.nlm.nih.gov/pubmed/28286787 http://dx.doi.org/10.1186/s40662-017-0072-z |
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author | Shoughy, Samir S. |
author_facet | Shoughy, Samir S. |
author_sort | Shoughy, Samir S. |
collection | PubMed |
description | Immune mediated inflammatory anterior segment diseases are variable and their management requires intense immunosuppression. Treatment with topical steroids is associated with serious ocular side effects. In order to overcome the potentially blinding complications of topical steroids, immunomodulatory drugs are being used more frequently. Tacrolimus is a calcineurin inhibitor that induces suppression of T lymphocytes activity and reduction of ocular inflammation. Tacrolimus was recently investigated for application in various anterior segment inflammatory disorders. In this review, we will discuss the therapeutic application of topical tacrolimus as a steroid-sparing agent in treating T cell mediated anterior segment inflammation. |
format | Online Article Text |
id | pubmed-5343311 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-53433112017-03-10 Topical tacrolimus in anterior segment inflammatory disorders Shoughy, Samir S. Eye Vis (Lond) Review Immune mediated inflammatory anterior segment diseases are variable and their management requires intense immunosuppression. Treatment with topical steroids is associated with serious ocular side effects. In order to overcome the potentially blinding complications of topical steroids, immunomodulatory drugs are being used more frequently. Tacrolimus is a calcineurin inhibitor that induces suppression of T lymphocytes activity and reduction of ocular inflammation. Tacrolimus was recently investigated for application in various anterior segment inflammatory disorders. In this review, we will discuss the therapeutic application of topical tacrolimus as a steroid-sparing agent in treating T cell mediated anterior segment inflammation. BioMed Central 2017-03-09 /pmc/articles/PMC5343311/ /pubmed/28286787 http://dx.doi.org/10.1186/s40662-017-0072-z Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Shoughy, Samir S. Topical tacrolimus in anterior segment inflammatory disorders |
title | Topical tacrolimus in anterior segment inflammatory disorders |
title_full | Topical tacrolimus in anterior segment inflammatory disorders |
title_fullStr | Topical tacrolimus in anterior segment inflammatory disorders |
title_full_unstemmed | Topical tacrolimus in anterior segment inflammatory disorders |
title_short | Topical tacrolimus in anterior segment inflammatory disorders |
title_sort | topical tacrolimus in anterior segment inflammatory disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343311/ https://www.ncbi.nlm.nih.gov/pubmed/28286787 http://dx.doi.org/10.1186/s40662-017-0072-z |
work_keys_str_mv | AT shoughysamirs topicaltacrolimusinanteriorsegmentinflammatorydisorders |