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Topical tacrolimus in anterior segment inflammatory disorders

Immune mediated inflammatory anterior segment diseases are variable and their management requires intense immunosuppression. Treatment with topical steroids is associated with serious ocular side effects. In order to overcome the potentially blinding complications of topical steroids, immunomodulato...

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Autor principal: Shoughy, Samir S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343311/
https://www.ncbi.nlm.nih.gov/pubmed/28286787
http://dx.doi.org/10.1186/s40662-017-0072-z
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author Shoughy, Samir S.
author_facet Shoughy, Samir S.
author_sort Shoughy, Samir S.
collection PubMed
description Immune mediated inflammatory anterior segment diseases are variable and their management requires intense immunosuppression. Treatment with topical steroids is associated with serious ocular side effects. In order to overcome the potentially blinding complications of topical steroids, immunomodulatory drugs are being used more frequently. Tacrolimus is a calcineurin inhibitor that induces suppression of T lymphocytes activity and reduction of ocular inflammation. Tacrolimus was recently investigated for application in various anterior segment inflammatory disorders. In this review, we will discuss the therapeutic application of topical tacrolimus as a steroid-sparing agent in treating T cell mediated anterior segment inflammation.
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spelling pubmed-53433112017-03-10 Topical tacrolimus in anterior segment inflammatory disorders Shoughy, Samir S. Eye Vis (Lond) Review Immune mediated inflammatory anterior segment diseases are variable and their management requires intense immunosuppression. Treatment with topical steroids is associated with serious ocular side effects. In order to overcome the potentially blinding complications of topical steroids, immunomodulatory drugs are being used more frequently. Tacrolimus is a calcineurin inhibitor that induces suppression of T lymphocytes activity and reduction of ocular inflammation. Tacrolimus was recently investigated for application in various anterior segment inflammatory disorders. In this review, we will discuss the therapeutic application of topical tacrolimus as a steroid-sparing agent in treating T cell mediated anterior segment inflammation. BioMed Central 2017-03-09 /pmc/articles/PMC5343311/ /pubmed/28286787 http://dx.doi.org/10.1186/s40662-017-0072-z Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Shoughy, Samir S.
Topical tacrolimus in anterior segment inflammatory disorders
title Topical tacrolimus in anterior segment inflammatory disorders
title_full Topical tacrolimus in anterior segment inflammatory disorders
title_fullStr Topical tacrolimus in anterior segment inflammatory disorders
title_full_unstemmed Topical tacrolimus in anterior segment inflammatory disorders
title_short Topical tacrolimus in anterior segment inflammatory disorders
title_sort topical tacrolimus in anterior segment inflammatory disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343311/
https://www.ncbi.nlm.nih.gov/pubmed/28286787
http://dx.doi.org/10.1186/s40662-017-0072-z
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