A randomized trial and novel SPR technique identifies altered lipoprotein-LDL receptor binding as a mechanism underlying elevated LDL-cholesterol in APOE4s

At a population level APOE4 carriers (~25% Caucasians) are at higher risk of cardiovascular diseases. The penetrance of genotype is however variable and influenced by dietary fat composition, with the APOE4 allele associated with greater LDL-cholesterol elevation in response to saturated fatty acids...

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Detalles Bibliográficos
Autores principales: Calabuig-Navarro, M. V., Jackson, K. G., Kemp, C. F., Leake, D. S., Walden, C. M., Lovegrove, J. A., Minihane, A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343425/
https://www.ncbi.nlm.nih.gov/pubmed/28276521
http://dx.doi.org/10.1038/srep44119

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