Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma

SHH Medulloblastoma (SHH-MB) is a pediatric brain tumor characterized by an inappropriate activation of the developmental Hedgehog (Hh) signaling. SHH-MB patients treated with the FDA-approved vismodegib, an Hh inhibitor that targets the transmembrane activator Smoothened (Smo), have shown the rapid...

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Detalles Bibliográficos
Autores principales: Coni, Sonia, Mancuso, Anna Barbara, Di Magno, Laura, Sdruscia, Giulia, Manni, Simona, Serrao, Silvia Maria, Rotili, Dante, Spiombi, Eleonora, Bufalieri, Francesca, Petroni, Marialaura, Kusio-Kobialka, Monika, De Smaele, Enrico, Ferretti, Elisabetta, Capalbo, Carlo, Mai, Antonello, Niewiadomski, Pawel, Screpanti, Isabella, Di Marcotullio, Lucia, Canettieri, Gianluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343431/
https://www.ncbi.nlm.nih.gov/pubmed/28276480
http://dx.doi.org/10.1038/srep44079

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