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Identification of berberine as a direct thrombin inhibitor from traditional Chinese medicine through structural, functional and binding studies

Thrombin acts as a key enzyme in the blood coagulation cascade and represents a potential drug target for the treatment of several cardiovascular diseases. The aim of this study was to identify small-molecule direct thrombin inhibitors from herbs used in traditional Chinese medicine (TCM). A pharmac...

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Detalles Bibliográficos
Autores principales:	Wang, Xing, Zhang, Yuxin, Yang, Ying, Wu, Xia, Fan, Hantian, Qiao, Yanjiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343495/ https://www.ncbi.nlm.nih.gov/pubmed/28276481 http://dx.doi.org/10.1038/srep44040

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