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Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development

TGF-β is known to influence tumour progression. Here we report an additional role of Smad3 in the tumour microenvironment regulating cancer progression. Deletion or inhibition of Smad3 in the tumour microenvironment suppresses tumour growth, invasion and metastasis in two syngeneic mouse tumour mode...

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Detalles Bibliográficos
Autores principales:	Tang, Patrick Ming-Kuen, Zhou, Shuang, Meng, Xiao-Ming, Wang, Qing-Ming, Li, Chun-Jie, Lian, Guang-Yu, Huang, Xiao-Ru, Tang, Yong-Jiang, Guan, Xin-Yuan, Yan, Bryan Ping-Yen, To, Ka-Fai, Lan, Hui-Yao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343519/ https://www.ncbi.nlm.nih.gov/pubmed/28262747 http://dx.doi.org/10.1038/ncomms14677

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