Malignant Transformation of an Intracranial Extradural Epidermoid Cyst into Squamous Cell Carcinoma Presented with Cerebrospinal Fluid Leakage

We report a case of malignant transformation of an intracranial extradural epidermoid cyst into squamous cell carcinoma (SCC), that presented with cerebrospinal fluid (CSF) leakage at the time of recurrence. Intracranial epidermoid cysts are histologically benign and slow-growing neoplasms. They are...

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Autores principales: Seif, Bahram, Pourkhalili, Reza, Shekarchizadeh, Ahmad, Mahzouni, Parvin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343612/
https://www.ncbi.nlm.nih.gov/pubmed/28299308
http://dx.doi.org/10.4103/2277-9175.200791
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author Seif, Bahram
Pourkhalili, Reza
Shekarchizadeh, Ahmad
Mahzouni, Parvin
author_facet Seif, Bahram
Pourkhalili, Reza
Shekarchizadeh, Ahmad
Mahzouni, Parvin
author_sort Seif, Bahram
collection PubMed
description We report a case of malignant transformation of an intracranial extradural epidermoid cyst into squamous cell carcinoma (SCC), that presented with cerebrospinal fluid (CSF) leakage at the time of recurrence. Intracranial epidermoid cysts are histologically benign and slow-growing neoplasms. They are congenital lesions that develop from ectodermal remnants during neuroembryogenesis. Malignant transformation of epidermoid cysts into SCC is very rare. Various clinical presentations of these tumors after malignant transformation are mentioned in the literature. None of the previous cases, presented with CSF leakage as the recent case did. In cases of malignant transformation, surgical resection and then adjuvant radiation therapy are highly recommended.
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spelling pubmed-53436122017-03-15 Malignant Transformation of an Intracranial Extradural Epidermoid Cyst into Squamous Cell Carcinoma Presented with Cerebrospinal Fluid Leakage Seif, Bahram Pourkhalili, Reza Shekarchizadeh, Ahmad Mahzouni, Parvin Adv Biomed Res Case Report We report a case of malignant transformation of an intracranial extradural epidermoid cyst into squamous cell carcinoma (SCC), that presented with cerebrospinal fluid (CSF) leakage at the time of recurrence. Intracranial epidermoid cysts are histologically benign and slow-growing neoplasms. They are congenital lesions that develop from ectodermal remnants during neuroembryogenesis. Malignant transformation of epidermoid cysts into SCC is very rare. Various clinical presentations of these tumors after malignant transformation are mentioned in the literature. None of the previous cases, presented with CSF leakage as the recent case did. In cases of malignant transformation, surgical resection and then adjuvant radiation therapy are highly recommended. Medknow Publications & Media Pvt Ltd 2017-02-22 /pmc/articles/PMC5343612/ /pubmed/28299308 http://dx.doi.org/10.4103/2277-9175.200791 Text en Copyright: © 2017 Advanced Biomedical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Seif, Bahram
Pourkhalili, Reza
Shekarchizadeh, Ahmad
Mahzouni, Parvin
Malignant Transformation of an Intracranial Extradural Epidermoid Cyst into Squamous Cell Carcinoma Presented with Cerebrospinal Fluid Leakage
title Malignant Transformation of an Intracranial Extradural Epidermoid Cyst into Squamous Cell Carcinoma Presented with Cerebrospinal Fluid Leakage
title_full Malignant Transformation of an Intracranial Extradural Epidermoid Cyst into Squamous Cell Carcinoma Presented with Cerebrospinal Fluid Leakage
title_fullStr Malignant Transformation of an Intracranial Extradural Epidermoid Cyst into Squamous Cell Carcinoma Presented with Cerebrospinal Fluid Leakage
title_full_unstemmed Malignant Transformation of an Intracranial Extradural Epidermoid Cyst into Squamous Cell Carcinoma Presented with Cerebrospinal Fluid Leakage
title_short Malignant Transformation of an Intracranial Extradural Epidermoid Cyst into Squamous Cell Carcinoma Presented with Cerebrospinal Fluid Leakage
title_sort malignant transformation of an intracranial extradural epidermoid cyst into squamous cell carcinoma presented with cerebrospinal fluid leakage
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343612/
https://www.ncbi.nlm.nih.gov/pubmed/28299308
http://dx.doi.org/10.4103/2277-9175.200791
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AT shekarchizadehahmad malignanttransformationofanintracranialextraduralepidermoidcystintosquamouscellcarcinomapresentedwithcerebrospinalfluidleakage
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