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Successful treatment of periodic paralysis with coenzyme Q10: two case reports

Primary periodic paralyses (PPs) are autosomal dominant ion channel disorders characterized by episodic flaccid weakness associated with variations in serum potassium level. The main prophylactic therapy of choice for PPsis carbonic anhydrase inhibitors that are not always effective. In this report,...

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Autores principales: Da, Yuwei, Lei, Lin, Jurkat-Rott, Karin, Lehmann-Horn, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pacini Editore SRL 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343741/
https://www.ncbi.nlm.nih.gov/pubmed/28344441
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author Da, Yuwei
Lei, Lin
Jurkat-Rott, Karin
Lehmann-Horn, Frank
author_facet Da, Yuwei
Lei, Lin
Jurkat-Rott, Karin
Lehmann-Horn, Frank
author_sort Da, Yuwei
collection PubMed
description Primary periodic paralyses (PPs) are autosomal dominant ion channel disorders characterized by episodic flaccid weakness associated with variations in serum potassium level. The main prophylactic therapy of choice for PPsis carbonic anhydrase inhibitors that are not always effective. In this report, we described two PP patients who were successfully treated with coenzyme Q10. They remained asymptomatic since initiation of treatment, which may be associated with promotion of energy synthesis, anti-oxidant activity, influence of the fiber type composition and regulation of the expression of gene. To our knowledge, this is the first report of primary periodic paralyses which have been successfully treated with CoQ10. More observations need to substantiate this clinical finding in PPs.
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spelling pubmed-53437412017-03-24 Successful treatment of periodic paralysis with coenzyme Q10: two case reports Da, Yuwei Lei, Lin Jurkat-Rott, Karin Lehmann-Horn, Frank Acta Myol Case Reports Primary periodic paralyses (PPs) are autosomal dominant ion channel disorders characterized by episodic flaccid weakness associated with variations in serum potassium level. The main prophylactic therapy of choice for PPsis carbonic anhydrase inhibitors that are not always effective. In this report, we described two PP patients who were successfully treated with coenzyme Q10. They remained asymptomatic since initiation of treatment, which may be associated with promotion of energy synthesis, anti-oxidant activity, influence of the fiber type composition and regulation of the expression of gene. To our knowledge, this is the first report of primary periodic paralyses which have been successfully treated with CoQ10. More observations need to substantiate this clinical finding in PPs. Pacini Editore SRL 2016-10 /pmc/articles/PMC5343741/ /pubmed/28344441 Text en The journal and the individual contributions contained in it are protected by the copyright of Gaetano Conte Academy, Naples, Italy http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License, which permits for noncommercial use, distribution, and reproduction in any digital medium, provided the original work is properly cited and is not altered in any way. For details, please refer to http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Case Reports
Da, Yuwei
Lei, Lin
Jurkat-Rott, Karin
Lehmann-Horn, Frank
Successful treatment of periodic paralysis with coenzyme Q10: two case reports
title Successful treatment of periodic paralysis with coenzyme Q10: two case reports
title_full Successful treatment of periodic paralysis with coenzyme Q10: two case reports
title_fullStr Successful treatment of periodic paralysis with coenzyme Q10: two case reports
title_full_unstemmed Successful treatment of periodic paralysis with coenzyme Q10: two case reports
title_short Successful treatment of periodic paralysis with coenzyme Q10: two case reports
title_sort successful treatment of periodic paralysis with coenzyme q10: two case reports
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343741/
https://www.ncbi.nlm.nih.gov/pubmed/28344441
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