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Eplerenone repolarizes muscle membrane through Na,K-ATPase activation by Tyr10 dephosphorylation

Eplerenone, an aldosterone antagonist, repolarizes muscle membrane in-vitro and increases strength in-vivo in channelopathies. In Duchenne dystrophy, it is administered for cardiomyopathy. We studied its mechanism of action on skeletal muscle to test its suitability for increasing strength in Duchen...

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Detalles Bibliográficos
Autores principales:	Breitenbach, Simon, Lehmann-Horn, Frank, Jurkat-Rott, Karin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Pacini Editore SRL 2016
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343744/ https://www.ncbi.nlm.nih.gov/pubmed/28344437

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