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Interaction of New-Developed TiO(2)-Based Photocatalytic Nanoparticles with Pathogenic Microorganisms and Human Dermal and Pulmonary Fibroblasts
TiO(2)-based photocatalysts were obtained during previous years in order to limit pollution and to ease human daily living conditions due to their special properties. However, obtaining biocompatible photocatalysts is still a key problem, and the mechanism of their toxicity recently received increas...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343786/ https://www.ncbi.nlm.nih.gov/pubmed/28125053 http://dx.doi.org/10.3390/ijms18020249 |
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author | Nica, Ionela Cristina Stan, Miruna Silvia Popa, Marcela Chifiriuc, Mariana Carmen Lazar, Veronica Pircalabioru, Gratiela G. Dumitrescu, Iuliana Ignat, Madalina Feder, Marcel Tanase, Liviu Cristian Mercioniu, Ionel Diamandescu, Lucian Dinischiotu, Anca |
author_facet | Nica, Ionela Cristina Stan, Miruna Silvia Popa, Marcela Chifiriuc, Mariana Carmen Lazar, Veronica Pircalabioru, Gratiela G. Dumitrescu, Iuliana Ignat, Madalina Feder, Marcel Tanase, Liviu Cristian Mercioniu, Ionel Diamandescu, Lucian Dinischiotu, Anca |
author_sort | Nica, Ionela Cristina |
collection | PubMed |
description | TiO(2)-based photocatalysts were obtained during previous years in order to limit pollution and to ease human daily living conditions due to their special properties. However, obtaining biocompatible photocatalysts is still a key problem, and the mechanism of their toxicity recently received increased attention. Two types of TiO(2) nanoparticles co-doped with 1% of iron and nitrogen (TiO(2)-1% Fe–N) atoms were synthesized in hydrothermal conditions at pH of 8.5 (HT1) and 5.5 (HT2), and their antimicrobial activity and cytotoxic effects exerted on human pulmonary and dermal fibroblasts were assessed. These particles exhibited significant microbicidal and anti-biofilm activity, suggesting their potential application for microbial decontamination of different environments. In addition, our results demonstrated the biocompatibility of TiO(2)-1% Fe–N nanoparticles at low doses on lung and dermal cells, which may initiate oxidative stress through dose accumulation. Although no significant changes were observed between the two tested photocatalysts, the biological response was cell type specific and time- and dose-dependent; the lung cells proved to be more sensitive to nanoparticle exposure. Taken together, these experimental data provide useful information for future photocatalytic applications in the industrial, food, pharmaceutical, and medical fields. |
format | Online Article Text |
id | pubmed-5343786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-53437862017-03-16 Interaction of New-Developed TiO(2)-Based Photocatalytic Nanoparticles with Pathogenic Microorganisms and Human Dermal and Pulmonary Fibroblasts Nica, Ionela Cristina Stan, Miruna Silvia Popa, Marcela Chifiriuc, Mariana Carmen Lazar, Veronica Pircalabioru, Gratiela G. Dumitrescu, Iuliana Ignat, Madalina Feder, Marcel Tanase, Liviu Cristian Mercioniu, Ionel Diamandescu, Lucian Dinischiotu, Anca Int J Mol Sci Article TiO(2)-based photocatalysts were obtained during previous years in order to limit pollution and to ease human daily living conditions due to their special properties. However, obtaining biocompatible photocatalysts is still a key problem, and the mechanism of their toxicity recently received increased attention. Two types of TiO(2) nanoparticles co-doped with 1% of iron and nitrogen (TiO(2)-1% Fe–N) atoms were synthesized in hydrothermal conditions at pH of 8.5 (HT1) and 5.5 (HT2), and their antimicrobial activity and cytotoxic effects exerted on human pulmonary and dermal fibroblasts were assessed. These particles exhibited significant microbicidal and anti-biofilm activity, suggesting their potential application for microbial decontamination of different environments. In addition, our results demonstrated the biocompatibility of TiO(2)-1% Fe–N nanoparticles at low doses on lung and dermal cells, which may initiate oxidative stress through dose accumulation. Although no significant changes were observed between the two tested photocatalysts, the biological response was cell type specific and time- and dose-dependent; the lung cells proved to be more sensitive to nanoparticle exposure. Taken together, these experimental data provide useful information for future photocatalytic applications in the industrial, food, pharmaceutical, and medical fields. MDPI 2017-01-25 /pmc/articles/PMC5343786/ /pubmed/28125053 http://dx.doi.org/10.3390/ijms18020249 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nica, Ionela Cristina Stan, Miruna Silvia Popa, Marcela Chifiriuc, Mariana Carmen Lazar, Veronica Pircalabioru, Gratiela G. Dumitrescu, Iuliana Ignat, Madalina Feder, Marcel Tanase, Liviu Cristian Mercioniu, Ionel Diamandescu, Lucian Dinischiotu, Anca Interaction of New-Developed TiO(2)-Based Photocatalytic Nanoparticles with Pathogenic Microorganisms and Human Dermal and Pulmonary Fibroblasts |
title | Interaction of New-Developed TiO(2)-Based Photocatalytic Nanoparticles with Pathogenic Microorganisms and Human Dermal and Pulmonary Fibroblasts |
title_full | Interaction of New-Developed TiO(2)-Based Photocatalytic Nanoparticles with Pathogenic Microorganisms and Human Dermal and Pulmonary Fibroblasts |
title_fullStr | Interaction of New-Developed TiO(2)-Based Photocatalytic Nanoparticles with Pathogenic Microorganisms and Human Dermal and Pulmonary Fibroblasts |
title_full_unstemmed | Interaction of New-Developed TiO(2)-Based Photocatalytic Nanoparticles with Pathogenic Microorganisms and Human Dermal and Pulmonary Fibroblasts |
title_short | Interaction of New-Developed TiO(2)-Based Photocatalytic Nanoparticles with Pathogenic Microorganisms and Human Dermal and Pulmonary Fibroblasts |
title_sort | interaction of new-developed tio(2)-based photocatalytic nanoparticles with pathogenic microorganisms and human dermal and pulmonary fibroblasts |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343786/ https://www.ncbi.nlm.nih.gov/pubmed/28125053 http://dx.doi.org/10.3390/ijms18020249 |
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