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Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer

Wisteria floribunda agglutinin (WFA) preferably binds to LacdiNAc glycans, and its reactivity is associated with tumor progression. The aim of this study to examine whether the serum LacdiNAc carrying prostate-specific antigen–glycosylation isomer (PSA-Gi) and WFA-reactivity of tumor tissue can be a...

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Autores principales: Hagiwara, Kazuhisa, Tobisawa, Yuki, Kaya, Takatoshi, Kaneko, Tomonori, Hatakeyama, Shingo, Mori, Kazuyuki, Hashimoto, Yasuhiro, Koie, Takuya, Suda, Yoshihiko, Ohyama, Chikara, Yoneyama, Tohru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343797/
https://www.ncbi.nlm.nih.gov/pubmed/28134773
http://dx.doi.org/10.3390/ijms18020261
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author Hagiwara, Kazuhisa
Tobisawa, Yuki
Kaya, Takatoshi
Kaneko, Tomonori
Hatakeyama, Shingo
Mori, Kazuyuki
Hashimoto, Yasuhiro
Koie, Takuya
Suda, Yoshihiko
Ohyama, Chikara
Yoneyama, Tohru
author_facet Hagiwara, Kazuhisa
Tobisawa, Yuki
Kaya, Takatoshi
Kaneko, Tomonori
Hatakeyama, Shingo
Mori, Kazuyuki
Hashimoto, Yasuhiro
Koie, Takuya
Suda, Yoshihiko
Ohyama, Chikara
Yoneyama, Tohru
author_sort Hagiwara, Kazuhisa
collection PubMed
description Wisteria floribunda agglutinin (WFA) preferably binds to LacdiNAc glycans, and its reactivity is associated with tumor progression. The aim of this study to examine whether the serum LacdiNAc carrying prostate-specific antigen–glycosylation isomer (PSA-Gi) and WFA-reactivity of tumor tissue can be applied as a diagnostic and prognostic marker of prostate cancer (PCa). Between 2007 and 2016, serum PSA-Gi levels before prostate biopsy (Pbx) were measured in 184 biopsy-proven benign prostatic hyperplasia patients and 244 PCa patients using an automated lectin-antibody immunoassay. WFA-reactivity on tumor was analyzed in 260 radical prostatectomy (RP) patients. Diagnostic and prognostic performance of serum PSA-Gi was evaluated using area under the receiver-operator characteristic curve (AUC). Prognostic performance of WFA-reactivity on tumor was evaluated via Cox proportional hazards regression analysis and nomogram. The AUC of serum PSA-Gi detecting PCa and predicting Pbx Grade Group (GG) 3 and GG ≥ 3 after RP was much higher than those of conventional PSA. Multivariate analysis showed that WFA-reactivity on prostate tumor was an independent risk factor of PSA recurrence. The nomogram was a strong model for predicting PSA-free survival provability with a c-index ≥0.7. Serum PSA-Gi levels and WFA-reactivity on prostate tumor may be a novel diagnostic and pre- and post-operative prognostic biomarkers of PCa, respectively.
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spelling pubmed-53437972017-03-16 Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer Hagiwara, Kazuhisa Tobisawa, Yuki Kaya, Takatoshi Kaneko, Tomonori Hatakeyama, Shingo Mori, Kazuyuki Hashimoto, Yasuhiro Koie, Takuya Suda, Yoshihiko Ohyama, Chikara Yoneyama, Tohru Int J Mol Sci Article Wisteria floribunda agglutinin (WFA) preferably binds to LacdiNAc glycans, and its reactivity is associated with tumor progression. The aim of this study to examine whether the serum LacdiNAc carrying prostate-specific antigen–glycosylation isomer (PSA-Gi) and WFA-reactivity of tumor tissue can be applied as a diagnostic and prognostic marker of prostate cancer (PCa). Between 2007 and 2016, serum PSA-Gi levels before prostate biopsy (Pbx) were measured in 184 biopsy-proven benign prostatic hyperplasia patients and 244 PCa patients using an automated lectin-antibody immunoassay. WFA-reactivity on tumor was analyzed in 260 radical prostatectomy (RP) patients. Diagnostic and prognostic performance of serum PSA-Gi was evaluated using area under the receiver-operator characteristic curve (AUC). Prognostic performance of WFA-reactivity on tumor was evaluated via Cox proportional hazards regression analysis and nomogram. The AUC of serum PSA-Gi detecting PCa and predicting Pbx Grade Group (GG) 3 and GG ≥ 3 after RP was much higher than those of conventional PSA. Multivariate analysis showed that WFA-reactivity on prostate tumor was an independent risk factor of PSA recurrence. The nomogram was a strong model for predicting PSA-free survival provability with a c-index ≥0.7. Serum PSA-Gi levels and WFA-reactivity on prostate tumor may be a novel diagnostic and pre- and post-operative prognostic biomarkers of PCa, respectively. MDPI 2017-01-26 /pmc/articles/PMC5343797/ /pubmed/28134773 http://dx.doi.org/10.3390/ijms18020261 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hagiwara, Kazuhisa
Tobisawa, Yuki
Kaya, Takatoshi
Kaneko, Tomonori
Hatakeyama, Shingo
Mori, Kazuyuki
Hashimoto, Yasuhiro
Koie, Takuya
Suda, Yoshihiko
Ohyama, Chikara
Yoneyama, Tohru
Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer
title Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer
title_full Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer
title_fullStr Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer
title_full_unstemmed Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer
title_short Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer
title_sort wisteria floribunda agglutinin and its reactive-glycan-carrying prostate-specific antigen as a novel diagnostic and prognostic marker of prostate cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343797/
https://www.ncbi.nlm.nih.gov/pubmed/28134773
http://dx.doi.org/10.3390/ijms18020261
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