Cargando…
Neurogenic Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer’s Disease
Hippocampal neurogenesis plays a critical role in the formation of new neurons during learning and memory development. Attenuation of neurogenesis in the brain is one of the primary causes of dementia in Alzheimer’s disease (AD), and, conversely, modulating the process of hippocampal neurogenesis be...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343808/ https://www.ncbi.nlm.nih.gov/pubmed/28134846 http://dx.doi.org/10.3390/ijms18020272 |
_version_ | 1782513428523384832 |
---|---|
author | Sreenivasmurthy, Sravan Gopalkrishnashetty Liu, Jing-Yi Song, Ju-Xian Yang, Chuan-Bin Malampati, Sandeep Wang, Zi-Ying Huang, Ying-Yu Li, Min |
author_facet | Sreenivasmurthy, Sravan Gopalkrishnashetty Liu, Jing-Yi Song, Ju-Xian Yang, Chuan-Bin Malampati, Sandeep Wang, Zi-Ying Huang, Ying-Yu Li, Min |
author_sort | Sreenivasmurthy, Sravan Gopalkrishnashetty |
collection | PubMed |
description | Hippocampal neurogenesis plays a critical role in the formation of new neurons during learning and memory development. Attenuation of neurogenesis in the brain is one of the primary causes of dementia in Alzheimer’s disease (AD), and, conversely, modulating the process of hippocampal neurogenesis benefit patients with AD. Traditional Chinese medicine (TCM), particularly herbal medicine, has been in use for thousands of years in Asia and many regions of the world for the treatment of cancer, cardiovascular diseases and neurodegenerative diseases. In this review, we summarize the role of neurotrophic factors, signal transducing factors, epigenetic modulators and neurotransmitters in neurogenesis, and we also discuss the functions of several Chinese herbs and their active molecules in activating multiple pathways involved in neurogenesis. TCM herbs target pathways such as Notch, Wnt, Sonic Hedgehog and receptor tyrosine kinase pathway, leading to activation of a signaling cascade that ultimately enhances the transcription of several important genes necessary for neurogenesis. Given these pathway activating effects, the use of TCM herbs could be an effective therapeutic strategy for the treatment of AD. |
format | Online Article Text |
id | pubmed-5343808 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-53438082017-03-16 Neurogenic Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer’s Disease Sreenivasmurthy, Sravan Gopalkrishnashetty Liu, Jing-Yi Song, Ju-Xian Yang, Chuan-Bin Malampati, Sandeep Wang, Zi-Ying Huang, Ying-Yu Li, Min Int J Mol Sci Review Hippocampal neurogenesis plays a critical role in the formation of new neurons during learning and memory development. Attenuation of neurogenesis in the brain is one of the primary causes of dementia in Alzheimer’s disease (AD), and, conversely, modulating the process of hippocampal neurogenesis benefit patients with AD. Traditional Chinese medicine (TCM), particularly herbal medicine, has been in use for thousands of years in Asia and many regions of the world for the treatment of cancer, cardiovascular diseases and neurodegenerative diseases. In this review, we summarize the role of neurotrophic factors, signal transducing factors, epigenetic modulators and neurotransmitters in neurogenesis, and we also discuss the functions of several Chinese herbs and their active molecules in activating multiple pathways involved in neurogenesis. TCM herbs target pathways such as Notch, Wnt, Sonic Hedgehog and receptor tyrosine kinase pathway, leading to activation of a signaling cascade that ultimately enhances the transcription of several important genes necessary for neurogenesis. Given these pathway activating effects, the use of TCM herbs could be an effective therapeutic strategy for the treatment of AD. MDPI 2017-01-28 /pmc/articles/PMC5343808/ /pubmed/28134846 http://dx.doi.org/10.3390/ijms18020272 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sreenivasmurthy, Sravan Gopalkrishnashetty Liu, Jing-Yi Song, Ju-Xian Yang, Chuan-Bin Malampati, Sandeep Wang, Zi-Ying Huang, Ying-Yu Li, Min Neurogenic Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer’s Disease |
title | Neurogenic Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer’s Disease |
title_full | Neurogenic Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer’s Disease |
title_fullStr | Neurogenic Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer’s Disease |
title_full_unstemmed | Neurogenic Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer’s Disease |
title_short | Neurogenic Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer’s Disease |
title_sort | neurogenic traditional chinese medicine as a promising strategy for the treatment of alzheimer’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343808/ https://www.ncbi.nlm.nih.gov/pubmed/28134846 http://dx.doi.org/10.3390/ijms18020272 |
work_keys_str_mv | AT sreenivasmurthysravangopalkrishnashetty neurogenictraditionalchinesemedicineasapromisingstrategyforthetreatmentofalzheimersdisease AT liujingyi neurogenictraditionalchinesemedicineasapromisingstrategyforthetreatmentofalzheimersdisease AT songjuxian neurogenictraditionalchinesemedicineasapromisingstrategyforthetreatmentofalzheimersdisease AT yangchuanbin neurogenictraditionalchinesemedicineasapromisingstrategyforthetreatmentofalzheimersdisease AT malampatisandeep neurogenictraditionalchinesemedicineasapromisingstrategyforthetreatmentofalzheimersdisease AT wangziying neurogenictraditionalchinesemedicineasapromisingstrategyforthetreatmentofalzheimersdisease AT huangyingyu neurogenictraditionalchinesemedicineasapromisingstrategyforthetreatmentofalzheimersdisease AT limin neurogenictraditionalchinesemedicineasapromisingstrategyforthetreatmentofalzheimersdisease |