Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice

This study investigated the prophylactic effects of orally administered surface-deacetylated chitin nanofibers (SDACNFs) and chitosan against 5-fluorouracil (5-FU)-induced intestinal mucositis, which is a common side effect of 5-FU chemotherapy. SDACNFs and chitosan abolished histological abnormalit...

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Detalles Bibliográficos
Autores principales: Koizumi, Ryo, Azuma, Kazuo, Izawa, Hironori, Morimoto, Minoru, Ochi, Kosuke, Tsuka, Takeshi, Imagawa, Tomohiro, Osaki, Tomohiro, Ito, Norihiko, Okamoto, Yoshiharu, Saimoto, Hiroyuki, Ifuku, Shinsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343815/
https://www.ncbi.nlm.nih.gov/pubmed/28134832
http://dx.doi.org/10.3390/ijms18020279
Descripción
Sumario:This study investigated the prophylactic effects of orally administered surface-deacetylated chitin nanofibers (SDACNFs) and chitosan against 5-fluorouracil (5-FU)-induced intestinal mucositis, which is a common side effect of 5-FU chemotherapy. SDACNFs and chitosan abolished histological abnormalities associated with intestinal mucositis and suppressed hypoproliferation and apoptosis of intestinal crypt cells. These results indicate that SDACNF and chitosan are useful agents for preventing mucositis induced by anti-cancer drugs.

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