Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice

This study investigated the prophylactic effects of orally administered surface-deacetylated chitin nanofibers (SDACNFs) and chitosan against 5-fluorouracil (5-FU)-induced intestinal mucositis, which is a common side effect of 5-FU chemotherapy. SDACNFs and chitosan abolished histological abnormalit...

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Autores principales: Koizumi, Ryo, Azuma, Kazuo, Izawa, Hironori, Morimoto, Minoru, Ochi, Kosuke, Tsuka, Takeshi, Imagawa, Tomohiro, Osaki, Tomohiro, Ito, Norihiko, Okamoto, Yoshiharu, Saimoto, Hiroyuki, Ifuku, Shinsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343815/
https://www.ncbi.nlm.nih.gov/pubmed/28134832
http://dx.doi.org/10.3390/ijms18020279
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author Koizumi, Ryo
Azuma, Kazuo
Izawa, Hironori
Morimoto, Minoru
Ochi, Kosuke
Tsuka, Takeshi
Imagawa, Tomohiro
Osaki, Tomohiro
Ito, Norihiko
Okamoto, Yoshiharu
Saimoto, Hiroyuki
Ifuku, Shinsuke
author_facet Koizumi, Ryo
Azuma, Kazuo
Izawa, Hironori
Morimoto, Minoru
Ochi, Kosuke
Tsuka, Takeshi
Imagawa, Tomohiro
Osaki, Tomohiro
Ito, Norihiko
Okamoto, Yoshiharu
Saimoto, Hiroyuki
Ifuku, Shinsuke
author_sort Koizumi, Ryo
collection PubMed
description This study investigated the prophylactic effects of orally administered surface-deacetylated chitin nanofibers (SDACNFs) and chitosan against 5-fluorouracil (5-FU)-induced intestinal mucositis, which is a common side effect of 5-FU chemotherapy. SDACNFs and chitosan abolished histological abnormalities associated with intestinal mucositis and suppressed hypoproliferation and apoptosis of intestinal crypt cells. These results indicate that SDACNF and chitosan are useful agents for preventing mucositis induced by anti-cancer drugs.
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spelling pubmed-53438152017-03-16 Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice Koizumi, Ryo Azuma, Kazuo Izawa, Hironori Morimoto, Minoru Ochi, Kosuke Tsuka, Takeshi Imagawa, Tomohiro Osaki, Tomohiro Ito, Norihiko Okamoto, Yoshiharu Saimoto, Hiroyuki Ifuku, Shinsuke Int J Mol Sci Article This study investigated the prophylactic effects of orally administered surface-deacetylated chitin nanofibers (SDACNFs) and chitosan against 5-fluorouracil (5-FU)-induced intestinal mucositis, which is a common side effect of 5-FU chemotherapy. SDACNFs and chitosan abolished histological abnormalities associated with intestinal mucositis and suppressed hypoproliferation and apoptosis of intestinal crypt cells. These results indicate that SDACNF and chitosan are useful agents for preventing mucositis induced by anti-cancer drugs. MDPI 2017-01-27 /pmc/articles/PMC5343815/ /pubmed/28134832 http://dx.doi.org/10.3390/ijms18020279 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Koizumi, Ryo
Azuma, Kazuo
Izawa, Hironori
Morimoto, Minoru
Ochi, Kosuke
Tsuka, Takeshi
Imagawa, Tomohiro
Osaki, Tomohiro
Ito, Norihiko
Okamoto, Yoshiharu
Saimoto, Hiroyuki
Ifuku, Shinsuke
Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice
title Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice
title_full Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice
title_fullStr Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice
title_full_unstemmed Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice
title_short Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice
title_sort oral administration of surface-deacetylated chitin nanofibers and chitosan inhibit 5-fluorouracil-induced intestinal mucositis in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343815/
https://www.ncbi.nlm.nih.gov/pubmed/28134832
http://dx.doi.org/10.3390/ijms18020279
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