Antimicrobial and Hemolytic Studies of a Series of Polycations Bearing Quaternary Ammonium Moieties: Structural and Topological Effects

A series of polycations bearing quaternary ammonium moieties have shown antimicrobial activity against the Gram-negative bacterium Escherichia coli. Different polymer topologies governed by a disubstituted aromatic core as well as different diamine-based linkers were found to influence the antimicro...

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Detalles Bibliográficos
Autores principales: Mayr, Judith, Bachl, Jürgen, Schlossmann, Jens, Díaz Díaz, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343839/
https://www.ncbi.nlm.nih.gov/pubmed/28146105
http://dx.doi.org/10.3390/ijms18020303
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author Mayr, Judith
Bachl, Jürgen
Schlossmann, Jens
Díaz Díaz, David
author_facet Mayr, Judith
Bachl, Jürgen
Schlossmann, Jens
Díaz Díaz, David
author_sort Mayr, Judith
collection PubMed
description A series of polycations bearing quaternary ammonium moieties have shown antimicrobial activity against the Gram-negative bacterium Escherichia coli. Different polymer topologies governed by a disubstituted aromatic core as well as different diamine-based linkers were found to influence the antimicrobial properties. Moreover, the hemolytic activity against human red blood cells was measured and demonstrated good biocompatibility and selectivity of these polycations for bacteria over mammalian cells.
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spelling pubmed-53438392017-03-16 Antimicrobial and Hemolytic Studies of a Series of Polycations Bearing Quaternary Ammonium Moieties: Structural and Topological Effects Mayr, Judith Bachl, Jürgen Schlossmann, Jens Díaz Díaz, David Int J Mol Sci Communication A series of polycations bearing quaternary ammonium moieties have shown antimicrobial activity against the Gram-negative bacterium Escherichia coli. Different polymer topologies governed by a disubstituted aromatic core as well as different diamine-based linkers were found to influence the antimicrobial properties. Moreover, the hemolytic activity against human red blood cells was measured and demonstrated good biocompatibility and selectivity of these polycations for bacteria over mammalian cells. MDPI 2017-01-30 /pmc/articles/PMC5343839/ /pubmed/28146105 http://dx.doi.org/10.3390/ijms18020303 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Mayr, Judith
Bachl, Jürgen
Schlossmann, Jens
Díaz Díaz, David
Antimicrobial and Hemolytic Studies of a Series of Polycations Bearing Quaternary Ammonium Moieties: Structural and Topological Effects
title Antimicrobial and Hemolytic Studies of a Series of Polycations Bearing Quaternary Ammonium Moieties: Structural and Topological Effects
title_full Antimicrobial and Hemolytic Studies of a Series of Polycations Bearing Quaternary Ammonium Moieties: Structural and Topological Effects
title_fullStr Antimicrobial and Hemolytic Studies of a Series of Polycations Bearing Quaternary Ammonium Moieties: Structural and Topological Effects
title_full_unstemmed Antimicrobial and Hemolytic Studies of a Series of Polycations Bearing Quaternary Ammonium Moieties: Structural and Topological Effects
title_short Antimicrobial and Hemolytic Studies of a Series of Polycations Bearing Quaternary Ammonium Moieties: Structural and Topological Effects
title_sort antimicrobial and hemolytic studies of a series of polycations bearing quaternary ammonium moieties: structural and topological effects
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343839/
https://www.ncbi.nlm.nih.gov/pubmed/28146105
http://dx.doi.org/10.3390/ijms18020303
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AT schlossmannjens antimicrobialandhemolyticstudiesofaseriesofpolycationsbearingquaternaryammoniummoietiesstructuralandtopologicaleffects
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