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Epigenetic Alterations in Parathyroid Cancers
Parathyroid cancers (PCas) are rare malignancies representing approximately 0.005% of all cancers. PCas are a rare cause of primary hyperparathyroidism, which is the third most common endocrine disease, mainly related to parathyroid benign tumors. About 90% of PCas are hormonally active hypersecreti...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343846/ https://www.ncbi.nlm.nih.gov/pubmed/28157158 http://dx.doi.org/10.3390/ijms18020310 |
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author | Verdelli, Chiara Corbetta, Sabrina |
author_facet | Verdelli, Chiara Corbetta, Sabrina |
author_sort | Verdelli, Chiara |
collection | PubMed |
description | Parathyroid cancers (PCas) are rare malignancies representing approximately 0.005% of all cancers. PCas are a rare cause of primary hyperparathyroidism, which is the third most common endocrine disease, mainly related to parathyroid benign tumors. About 90% of PCas are hormonally active hypersecreting parathormone (PTH); consequently patients present with complications of severe hypercalcemia. Pre-operative diagnosis is often difficult due to clinical features shared with benign parathyroid lesions. Surgery provides the current best chance of cure, though persistent or recurrent disease occurs in about 50% of patients with PCas. Somatic inactivating mutations of CDC73/HRPT2 gene, encoding parafibromin, are the most frequent genetic anomalies occurring in PCas. Recently, the aberrant DNA methylation signature and microRNA expression profile have been identified in PCas, providing evidence that parathyroid malignancies are distinct entities from parathyroid benign lesions, showing an epigenetic signature resembling some embryonic aspects. The present paper reviews data about epigenetic alterations in PCas, up to now limited to DNA methylation, chromatin regulators and microRNA profile. |
format | Online Article Text |
id | pubmed-5343846 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-53438462017-03-16 Epigenetic Alterations in Parathyroid Cancers Verdelli, Chiara Corbetta, Sabrina Int J Mol Sci Review Parathyroid cancers (PCas) are rare malignancies representing approximately 0.005% of all cancers. PCas are a rare cause of primary hyperparathyroidism, which is the third most common endocrine disease, mainly related to parathyroid benign tumors. About 90% of PCas are hormonally active hypersecreting parathormone (PTH); consequently patients present with complications of severe hypercalcemia. Pre-operative diagnosis is often difficult due to clinical features shared with benign parathyroid lesions. Surgery provides the current best chance of cure, though persistent or recurrent disease occurs in about 50% of patients with PCas. Somatic inactivating mutations of CDC73/HRPT2 gene, encoding parafibromin, are the most frequent genetic anomalies occurring in PCas. Recently, the aberrant DNA methylation signature and microRNA expression profile have been identified in PCas, providing evidence that parathyroid malignancies are distinct entities from parathyroid benign lesions, showing an epigenetic signature resembling some embryonic aspects. The present paper reviews data about epigenetic alterations in PCas, up to now limited to DNA methylation, chromatin regulators and microRNA profile. MDPI 2017-02-01 /pmc/articles/PMC5343846/ /pubmed/28157158 http://dx.doi.org/10.3390/ijms18020310 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Verdelli, Chiara Corbetta, Sabrina Epigenetic Alterations in Parathyroid Cancers |
title | Epigenetic Alterations in Parathyroid Cancers |
title_full | Epigenetic Alterations in Parathyroid Cancers |
title_fullStr | Epigenetic Alterations in Parathyroid Cancers |
title_full_unstemmed | Epigenetic Alterations in Parathyroid Cancers |
title_short | Epigenetic Alterations in Parathyroid Cancers |
title_sort | epigenetic alterations in parathyroid cancers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343846/ https://www.ncbi.nlm.nih.gov/pubmed/28157158 http://dx.doi.org/10.3390/ijms18020310 |
work_keys_str_mv | AT verdellichiara epigeneticalterationsinparathyroidcancers AT corbettasabrina epigeneticalterationsinparathyroidcancers |