Cargando…

Single-Nucleotide Polymorphism of PPARγ, a Protein at the Crossroads of Physiological and Pathological Processes

Genome polymorphisms are responsible for phenotypic differences between humans and for individual susceptibility to genetic diseases and therapeutic responses. Non-synonymous single-nucleotide polymorphisms (nsSNPs) lead to protein variants with a change in the amino acid sequence that may affect th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Petrosino, Maria, Lori, Laura, Pasquo, Alessandra, Lori, Clorinda, Consalvi, Valerio, Minicozzi, Velia, Morante, Silvia, Laghezza, Antonio, Giorgi, Alessandra, Capelli, Davide, Chiaraluce, Roberta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343896/ https://www.ncbi.nlm.nih.gov/pubmed/28208577 http://dx.doi.org/10.3390/ijms18020361

Ejemplares similares

Effect of BET Missense Mutations on Bromodomain Function, Inhibitor Binding and Stability
por: Lori, Laura, et al.
Publicado: (2016)

The complex impact of cancer-related missense mutations on the stability and on the biophysical and biochemical properties of MAPK1 and MAPK3 somatic variants
por: Petrosino, Maria, et al.
Publicado: (2023)

Effect of Single Amino Acid Substitution Observed in Cancer on Pim-1 Kinase Thermodynamic Stability and Structure
por: Lori, Clorinda, et al.
Publicado: (2013)

Unveiling the folding mechanism of the Bromodomains
por: Petrosino, Maria, et al.
Publicado: (2017)

Zn‐Induced Interactions Between SARS‐CoV‐2 orf7a and BST2/Tetherin
por: Petrosino, Maria, et al.
Publicado: (2021)

Analysis and Interpretation of the Impact of Missense Variants in Cancer
por: Petrosino, Maria, et al.
Publicado: (2021)

Mutation in the Common Docking Domain Affects MAP Kinase ERK2 Catalysis and Stability
por: Novak, Leonore, et al.
Publicado: (2023)

The phosphoglycerate kinase 1 variants found in carcinoma cells display different catalytic activity and conformational stability compared to the native enzyme
por: Fiorillo, Annarita, et al.
Publicado: (2018)

A Glimpse into the Structural Properties of the Intermediate and Transition State in the Folding of Bromodomain 2 Domain 2 by Φ Value Analysis
por: Novak, Leonore, et al.
Publicado: (2021)

Structural Stability of Human Protein Tyrosine Phosphatase ρ Catalytic Domain: Effect of Point Mutations
por: Pasquo, Alessandra, et al.
Publicado: (2012)

The role of Zn ions in the interaction between SARS-CoV-2 orf7a protein and BST2/tetherin
por: Botticelli, S., et al.
Publicado: (2023)

Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin
por: Montanari, Roberta, et al.
Publicado: (2016)

Metal Ion Binding in Wild-Type and Mutated Frataxin: A Stability Study
por: Morante, S., et al.
Publicado: (2022)

Biological Screening and Crystallographic Studies of Hydroxy γ-Lactone Derivatives to Investigate PPARγ Phosphorylation Inhibition
por: Capelli, Davide, et al.
Publicado: (2023)

Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis
por: Brusotti, Gloria, et al.
Publicado: (2017)

Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode
por: Capelli, Davide, et al.
Publicado: (2016)

PPAR-γ Thiazolidinedione Agonists and Immunotherapy in the Treatment of Brain Tumors
por: Lichtor, Terry, et al.
Publicado: (2008)

PPARs at the crossroads of T cell differentiation and type 1 diabetes
por: Riaz, Farooq, et al.
Publicado: (2023)

PPARγ in Kidney Physiology and Pathophysiology
por: Kiss-Tóth, Éva, et al.
Publicado: (2008)

PPARγ in Neuroblastoma
por: Peri, Alessandro, et al.
Publicado: (2008)

Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases
por: Kulkarni, Ajit A., et al.
Publicado: (2012)

Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARγ Agonists and their Antidiabetic Effects on Type 2 Diabetes
por: Yasmin, Sabina, et al.
Publicado: (2017)

A Single Nucleotide Variant in the PPARγ-homolog Eip75B Affects Fecundity in Drosophila
por: Hoedjes, Katja M, et al.
Publicado: (2023)

Mitochondria at the Crossroads of Physiology and Pathology
por: Moro, Loredana
Publicado: (2020)

PPARγ and Apoptosis in Cancer
por: Elrod, Heath A., et al.
Publicado: (2008)

PPARγ, neuroinflammation, and disease
por: Mrak, Robert E, et al.
Publicado: (2004)

Nutraceuticals as Ligands of PPARγ
por: Penumetcha, Meera, et al.
Publicado: (2012)

PPARγ and Cognitive Performance
por: d’Angelo, Michele, et al.
Publicado: (2019)

Phosphorylation of PPARγ Affects the Collective Motions of the PPARγ-RXRα-DNA Complex
por: Lemkul, Justin A., et al.
Publicado: (2015)

PPARγ and PPARδ as Modulators of Neoplasia and Cell Fate
por: Glazer, Robert I., et al.
Publicado: (2008)

The Contribution of EDF1 to PPARγ Transcriptional Activation in VEGF-Treated Human Endothelial Cells
por: Cazzaniga, Alessandra, et al.
Publicado: (2018)

Comparative Gene Expression Profiles Induced by PPARγ and PPARα/γ Agonists in Human Hepatocytes
por: Rogue, Alexandra, et al.
Publicado: (2011)

Scaffold-Based Pan-Agonist Design for the PPARα, PPARβ and PPARγ Receptors
por: Zhang, Li-Song, et al.
Publicado: (2012)

CD99 at the crossroads of physiology and pathology
por: Pasello, Michela, et al.
Publicado: (2018)

Myelopoiesis, metabolism and therapy: a crucial crossroads in cancer progression
por: Sica, Antonio, et al.
Publicado: (2019)

PPARγ and MEK Interactions in Cancer
por: Burgermeister, Elke, et al.
Publicado: (2008)

PPARγ and Proline Oxidase in Cancer
por: Phang, James M., et al.
Publicado: (2008)

The Role of PPARγ in Hepatocellular Carcinoma
por: Borbath, Ivan, et al.
Publicado: (2008)

Nuclear receptor corepressors and PPARγ
por: Cohen, Ronald N.
Publicado: (2006)

PPARγ tackles treacherous T cells
por: Leslie, Mitch
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_a2luu76rmos29hdumbbq837um1