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Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer
Non-small-cell lung cancer (NSCLC) constitutes 85% of all lung cancers, and is the leading cause of cancer-related death worldwide. The poor prognosis and resistance to both radiation and chemotherapy warrant further investigation into the molecular mechanisms of NSCLC and the development of new, mo...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343902/ https://www.ncbi.nlm.nih.gov/pubmed/28208579 http://dx.doi.org/10.3390/ijms18020367 |
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author | Liu, Guangbo Pei, Fen Yang, Fengqing Li, Lingxiao Amin, Amit Dipak Liu, Songnian Buchan, J. Ross Cho, William C. |
author_facet | Liu, Guangbo Pei, Fen Yang, Fengqing Li, Lingxiao Amin, Amit Dipak Liu, Songnian Buchan, J. Ross Cho, William C. |
author_sort | Liu, Guangbo |
collection | PubMed |
description | Non-small-cell lung cancer (NSCLC) constitutes 85% of all lung cancers, and is the leading cause of cancer-related death worldwide. The poor prognosis and resistance to both radiation and chemotherapy warrant further investigation into the molecular mechanisms of NSCLC and the development of new, more efficacious therapeutics. The processes of autophagy and apoptosis, which induce degradation of proteins and organelles or cell death upon cellular stress, are crucial in the pathophysiology of NSCLC. The close interplay between autophagy and apoptosis through shared signaling pathways complicates our understanding of how NSCLC pathophysiology is regulated. The apoptotic effect of autophagy is controversial as both inhibitory and stimulatory effects have been reported in NSCLC. In addition, crosstalk of proteins regulating both autophagy and apoptosis exists. Here, we review the recent advances of the relationship between autophagy and apoptosis in NSCLC, aiming to provide few insights into the discovery of novel pathogenic factors and the development of new cancer therapeutics. |
format | Online Article Text |
id | pubmed-5343902 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-53439022017-03-16 Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer Liu, Guangbo Pei, Fen Yang, Fengqing Li, Lingxiao Amin, Amit Dipak Liu, Songnian Buchan, J. Ross Cho, William C. Int J Mol Sci Review Non-small-cell lung cancer (NSCLC) constitutes 85% of all lung cancers, and is the leading cause of cancer-related death worldwide. The poor prognosis and resistance to both radiation and chemotherapy warrant further investigation into the molecular mechanisms of NSCLC and the development of new, more efficacious therapeutics. The processes of autophagy and apoptosis, which induce degradation of proteins and organelles or cell death upon cellular stress, are crucial in the pathophysiology of NSCLC. The close interplay between autophagy and apoptosis through shared signaling pathways complicates our understanding of how NSCLC pathophysiology is regulated. The apoptotic effect of autophagy is controversial as both inhibitory and stimulatory effects have been reported in NSCLC. In addition, crosstalk of proteins regulating both autophagy and apoptosis exists. Here, we review the recent advances of the relationship between autophagy and apoptosis in NSCLC, aiming to provide few insights into the discovery of novel pathogenic factors and the development of new cancer therapeutics. MDPI 2017-02-10 /pmc/articles/PMC5343902/ /pubmed/28208579 http://dx.doi.org/10.3390/ijms18020367 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Liu, Guangbo Pei, Fen Yang, Fengqing Li, Lingxiao Amin, Amit Dipak Liu, Songnian Buchan, J. Ross Cho, William C. Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer |
title | Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer |
title_full | Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer |
title_fullStr | Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer |
title_full_unstemmed | Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer |
title_short | Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer |
title_sort | role of autophagy and apoptosis in non-small-cell lung cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343902/ https://www.ncbi.nlm.nih.gov/pubmed/28208579 http://dx.doi.org/10.3390/ijms18020367 |
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