Role of Splice Variants of Gtf2i, a Transcription Factor Localizing at Postsynaptic Sites, and Its Relation to Neuropsychiatric Diseases

We previously reported that various mRNAs were associated with postsynaptic density (PSD) purified from rat forebrain. Among the thousands of PSD-associated mRNAs, we highlight the biology of the general transcription factor II-I (Gtf2i) mRNA, focusing on the significance of its versatile splicing f...

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Detalles Bibliográficos
Autores principales: Shirai, Yoshinori, Li, Weidong, Suzuki, Tatsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343945/
https://www.ncbi.nlm.nih.gov/pubmed/28212274
http://dx.doi.org/10.3390/ijms18020411
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author Shirai, Yoshinori
Li, Weidong
Suzuki, Tatsuo
author_facet Shirai, Yoshinori
Li, Weidong
Suzuki, Tatsuo
author_sort Shirai, Yoshinori
collection PubMed
description We previously reported that various mRNAs were associated with postsynaptic density (PSD) purified from rat forebrain. Among the thousands of PSD-associated mRNAs, we highlight the biology of the general transcription factor II-I (Gtf2i) mRNA, focusing on the significance of its versatile splicing for targeting its own mRNA into dendrites, regulation of translation, and the effects of Gtf2i expression level as well as its relationship with neuropsychiatric disorders.
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spelling pubmed-53439452017-03-16 Role of Splice Variants of Gtf2i, a Transcription Factor Localizing at Postsynaptic Sites, and Its Relation to Neuropsychiatric Diseases Shirai, Yoshinori Li, Weidong Suzuki, Tatsuo Int J Mol Sci Review We previously reported that various mRNAs were associated with postsynaptic density (PSD) purified from rat forebrain. Among the thousands of PSD-associated mRNAs, we highlight the biology of the general transcription factor II-I (Gtf2i) mRNA, focusing on the significance of its versatile splicing for targeting its own mRNA into dendrites, regulation of translation, and the effects of Gtf2i expression level as well as its relationship with neuropsychiatric disorders. MDPI 2017-02-15 /pmc/articles/PMC5343945/ /pubmed/28212274 http://dx.doi.org/10.3390/ijms18020411 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shirai, Yoshinori
Li, Weidong
Suzuki, Tatsuo
Role of Splice Variants of Gtf2i, a Transcription Factor Localizing at Postsynaptic Sites, and Its Relation to Neuropsychiatric Diseases
title Role of Splice Variants of Gtf2i, a Transcription Factor Localizing at Postsynaptic Sites, and Its Relation to Neuropsychiatric Diseases
title_full Role of Splice Variants of Gtf2i, a Transcription Factor Localizing at Postsynaptic Sites, and Its Relation to Neuropsychiatric Diseases
title_fullStr Role of Splice Variants of Gtf2i, a Transcription Factor Localizing at Postsynaptic Sites, and Its Relation to Neuropsychiatric Diseases
title_full_unstemmed Role of Splice Variants of Gtf2i, a Transcription Factor Localizing at Postsynaptic Sites, and Its Relation to Neuropsychiatric Diseases
title_short Role of Splice Variants of Gtf2i, a Transcription Factor Localizing at Postsynaptic Sites, and Its Relation to Neuropsychiatric Diseases
title_sort role of splice variants of gtf2i, a transcription factor localizing at postsynaptic sites, and its relation to neuropsychiatric diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343945/
https://www.ncbi.nlm.nih.gov/pubmed/28212274
http://dx.doi.org/10.3390/ijms18020411
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