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Metabolic Effects of Berries with Structurally Diverse Anthocyanins

Overconsumption of energy dense foods and sedentary lifestyle are considered as major causes of obesity-associated insulin resistance and abnormal glucose metabolism. Results from both cohort studies and randomized trials suggested that anthocyanins from berries may lower metabolic risks, however th...

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Autores principales: Overall, John, Bonney, Sierra A., Wilson, Mickey, Beermann, Arnold, Grace, Mary H., Esposito, Debora, Lila, Mary Ann, Komarnytsky, Slavko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343956/
https://www.ncbi.nlm.nih.gov/pubmed/28212306
http://dx.doi.org/10.3390/ijms18020422
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author Overall, John
Bonney, Sierra A.
Wilson, Mickey
Beermann, Arnold
Grace, Mary H.
Esposito, Debora
Lila, Mary Ann
Komarnytsky, Slavko
author_facet Overall, John
Bonney, Sierra A.
Wilson, Mickey
Beermann, Arnold
Grace, Mary H.
Esposito, Debora
Lila, Mary Ann
Komarnytsky, Slavko
author_sort Overall, John
collection PubMed
description Overconsumption of energy dense foods and sedentary lifestyle are considered as major causes of obesity-associated insulin resistance and abnormal glucose metabolism. Results from both cohort studies and randomized trials suggested that anthocyanins from berries may lower metabolic risks, however these reports are equivocal. The present study was designed to examine effects of six berries with structurally diverse anthocyanin profiles (normalized to 400 µg/g total anthocyanin content) on development of metabolic risk factors in the C57BL/6 mouse model of polygenic obesity. Diets supplemented with blackberry (mono-glycosylated cyanidins), black raspberry (acylated mono-glycosylated cyanidins), blackcurrant (mono- and di-glycosylated cyanidins and delphinidins), maqui berry (di-glycosylated delphinidins), Concord grape (acylated mono-glycosylated delphinidins and petunidins), and blueberry (mono-glycosylated delphinidins, malvidins, and petunidins) showed a prominent discrepancy between biological activities of delphinidin/malvidin-versus cyanidin-type anthocyanins that could be explained by differences in their structure and metabolism in the gut. Consumption of berries also resulted in a strong shift in the gastrointestinal bacterial communities towards obligate anaerobes that correlated with decrease in the gastrointestinal luminal oxygen and oxidative stress. Further work is needed to understand mechanisms that lead to nearly anoxic conditions in the gut lumens, including the relative contributions of host, diet and/or microbial oxidative activity, and their implication to human health.
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spelling pubmed-53439562017-03-16 Metabolic Effects of Berries with Structurally Diverse Anthocyanins Overall, John Bonney, Sierra A. Wilson, Mickey Beermann, Arnold Grace, Mary H. Esposito, Debora Lila, Mary Ann Komarnytsky, Slavko Int J Mol Sci Article Overconsumption of energy dense foods and sedentary lifestyle are considered as major causes of obesity-associated insulin resistance and abnormal glucose metabolism. Results from both cohort studies and randomized trials suggested that anthocyanins from berries may lower metabolic risks, however these reports are equivocal. The present study was designed to examine effects of six berries with structurally diverse anthocyanin profiles (normalized to 400 µg/g total anthocyanin content) on development of metabolic risk factors in the C57BL/6 mouse model of polygenic obesity. Diets supplemented with blackberry (mono-glycosylated cyanidins), black raspberry (acylated mono-glycosylated cyanidins), blackcurrant (mono- and di-glycosylated cyanidins and delphinidins), maqui berry (di-glycosylated delphinidins), Concord grape (acylated mono-glycosylated delphinidins and petunidins), and blueberry (mono-glycosylated delphinidins, malvidins, and petunidins) showed a prominent discrepancy between biological activities of delphinidin/malvidin-versus cyanidin-type anthocyanins that could be explained by differences in their structure and metabolism in the gut. Consumption of berries also resulted in a strong shift in the gastrointestinal bacterial communities towards obligate anaerobes that correlated with decrease in the gastrointestinal luminal oxygen and oxidative stress. Further work is needed to understand mechanisms that lead to nearly anoxic conditions in the gut lumens, including the relative contributions of host, diet and/or microbial oxidative activity, and their implication to human health. MDPI 2017-02-15 /pmc/articles/PMC5343956/ /pubmed/28212306 http://dx.doi.org/10.3390/ijms18020422 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Overall, John
Bonney, Sierra A.
Wilson, Mickey
Beermann, Arnold
Grace, Mary H.
Esposito, Debora
Lila, Mary Ann
Komarnytsky, Slavko
Metabolic Effects of Berries with Structurally Diverse Anthocyanins
title Metabolic Effects of Berries with Structurally Diverse Anthocyanins
title_full Metabolic Effects of Berries with Structurally Diverse Anthocyanins
title_fullStr Metabolic Effects of Berries with Structurally Diverse Anthocyanins
title_full_unstemmed Metabolic Effects of Berries with Structurally Diverse Anthocyanins
title_short Metabolic Effects of Berries with Structurally Diverse Anthocyanins
title_sort metabolic effects of berries with structurally diverse anthocyanins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343956/
https://www.ncbi.nlm.nih.gov/pubmed/28212306
http://dx.doi.org/10.3390/ijms18020422
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