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Matrix Metalloproteinases as Regulators of Periodontal Inflammation
Periodontitis are infectious diseases characterized by immune-mediated destruction of periodontal supporting tissues and tooth loss. Matrix metalloproteinases (MMPs) are key proteases involved in destructive periodontal diseases. The study and interest in MMP has been fuelled by emerging evidence de...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343974/ https://www.ncbi.nlm.nih.gov/pubmed/28218665 http://dx.doi.org/10.3390/ijms18020440 |
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author | Franco, Cavalla Patricia, Hernández-Ríos Timo, Sorsa Claudia, Biguetti Marcela, Hernández |
author_facet | Franco, Cavalla Patricia, Hernández-Ríos Timo, Sorsa Claudia, Biguetti Marcela, Hernández |
author_sort | Franco, Cavalla |
collection | PubMed |
description | Periodontitis are infectious diseases characterized by immune-mediated destruction of periodontal supporting tissues and tooth loss. Matrix metalloproteinases (MMPs) are key proteases involved in destructive periodontal diseases. The study and interest in MMP has been fuelled by emerging evidence demonstrating the broad spectrum of molecules that can be cleaved by them and the myriad of biological processes that they can potentially regulate. The huge complexity of MMP functions within the ‘protease web’ is crucial for many physiologic and pathologic processes, including immunity, inflammation, bone resorption, and wound healing. Evidence points out that MMPs assemble in activation cascades and besides their classical extracellular matrix substrates, they cleave several signalling molecules—such as cytokines, chemokines, and growth factors, among others—regulating their biological functions and/or bioavailability during periodontal diseases. In this review, we provide an overview of emerging evidence of MMPs as regulators of periodontal inflammation. |
format | Online Article Text |
id | pubmed-5343974 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-53439742017-03-16 Matrix Metalloproteinases as Regulators of Periodontal Inflammation Franco, Cavalla Patricia, Hernández-Ríos Timo, Sorsa Claudia, Biguetti Marcela, Hernández Int J Mol Sci Review Periodontitis are infectious diseases characterized by immune-mediated destruction of periodontal supporting tissues and tooth loss. Matrix metalloproteinases (MMPs) are key proteases involved in destructive periodontal diseases. The study and interest in MMP has been fuelled by emerging evidence demonstrating the broad spectrum of molecules that can be cleaved by them and the myriad of biological processes that they can potentially regulate. The huge complexity of MMP functions within the ‘protease web’ is crucial for many physiologic and pathologic processes, including immunity, inflammation, bone resorption, and wound healing. Evidence points out that MMPs assemble in activation cascades and besides their classical extracellular matrix substrates, they cleave several signalling molecules—such as cytokines, chemokines, and growth factors, among others—regulating their biological functions and/or bioavailability during periodontal diseases. In this review, we provide an overview of emerging evidence of MMPs as regulators of periodontal inflammation. MDPI 2017-02-17 /pmc/articles/PMC5343974/ /pubmed/28218665 http://dx.doi.org/10.3390/ijms18020440 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Franco, Cavalla Patricia, Hernández-Ríos Timo, Sorsa Claudia, Biguetti Marcela, Hernández Matrix Metalloproteinases as Regulators of Periodontal Inflammation |
title | Matrix Metalloproteinases as Regulators of Periodontal Inflammation |
title_full | Matrix Metalloproteinases as Regulators of Periodontal Inflammation |
title_fullStr | Matrix Metalloproteinases as Regulators of Periodontal Inflammation |
title_full_unstemmed | Matrix Metalloproteinases as Regulators of Periodontal Inflammation |
title_short | Matrix Metalloproteinases as Regulators of Periodontal Inflammation |
title_sort | matrix metalloproteinases as regulators of periodontal inflammation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343974/ https://www.ncbi.nlm.nih.gov/pubmed/28218665 http://dx.doi.org/10.3390/ijms18020440 |
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