ApoSOD1 lacking dismutase activity neuroprotects motor neurons exposed to beta-methylamino-L-alanine through the Ca(2+)/Akt/ERK1/2 prosurvival pathway

Amyotrophic lateral sclerosis (ALS) is a severe human adult-onset neurodegenerative disease affecting lower and upper motor neurons. In >20% of cases, the familial form of ALS is caused by mutations in the gene encoding Cu,Zn-superoxide dismutase (SOD1). Interestingly, administration of wild-type...

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Detalles Bibliográficos
Autores principales: Petrozziello, Tiziana, Secondo, Agnese, Tedeschi, Valentina, Esposito, Alba, Sisalli, MariaJosè, Scorziello, Antonella, Di Renzo, Gianfranco, Annunziato, Lucio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344211/
https://www.ncbi.nlm.nih.gov/pubmed/28085149
http://dx.doi.org/10.1038/cdd.2016.154

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