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Tumor-Associated Macrophages in Oncolytic Virotherapy: Friend or Foe?

Cancer therapy remains a challenge due to toxicity limitations of chemotherapy and radiation therapy. Oncolytic viruses that selectively replicate and destroy cancer cells are of increasing interest. In addition to direct cell lysis, these vectors stimulate an anti-tumor immune response. A key regul...

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Autores principales: Denton, Nicholas L., Chen, Chun-Yu, Scott, Thomas R., Cripe, Timothy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344259/
https://www.ncbi.nlm.nih.gov/pubmed/28536380
http://dx.doi.org/10.3390/biomedicines4030013
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author Denton, Nicholas L.
Chen, Chun-Yu
Scott, Thomas R.
Cripe, Timothy P.
author_facet Denton, Nicholas L.
Chen, Chun-Yu
Scott, Thomas R.
Cripe, Timothy P.
author_sort Denton, Nicholas L.
collection PubMed
description Cancer therapy remains a challenge due to toxicity limitations of chemotherapy and radiation therapy. Oncolytic viruses that selectively replicate and destroy cancer cells are of increasing interest. In addition to direct cell lysis, these vectors stimulate an anti-tumor immune response. A key regulator of tumor immunity is the tumor-associated macrophage population. Macrophages can either support oncolytic virus therapy through pro-inflammatory stimulation of the anti-tumor response at the cost of hindering direct oncolysis or through immunosuppressive protection of virus replication at the cost of hindering the anti-tumor immune response. Despite similarities in macrophage interaction between adult and pediatric tumors and the abundance of research supporting macrophage modulation in adult tumors, there are few studies investigating macrophage modulation in pediatric cancers or modulation of immunotherapy. We review the current state of knowledge regarding macrophages in cancers and their influence on oncolytic virotherapy.
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spelling pubmed-53442592017-05-23 Tumor-Associated Macrophages in Oncolytic Virotherapy: Friend or Foe? Denton, Nicholas L. Chen, Chun-Yu Scott, Thomas R. Cripe, Timothy P. Biomedicines Review Cancer therapy remains a challenge due to toxicity limitations of chemotherapy and radiation therapy. Oncolytic viruses that selectively replicate and destroy cancer cells are of increasing interest. In addition to direct cell lysis, these vectors stimulate an anti-tumor immune response. A key regulator of tumor immunity is the tumor-associated macrophage population. Macrophages can either support oncolytic virus therapy through pro-inflammatory stimulation of the anti-tumor response at the cost of hindering direct oncolysis or through immunosuppressive protection of virus replication at the cost of hindering the anti-tumor immune response. Despite similarities in macrophage interaction between adult and pediatric tumors and the abundance of research supporting macrophage modulation in adult tumors, there are few studies investigating macrophage modulation in pediatric cancers or modulation of immunotherapy. We review the current state of knowledge regarding macrophages in cancers and their influence on oncolytic virotherapy. MDPI 2016-07-07 /pmc/articles/PMC5344259/ /pubmed/28536380 http://dx.doi.org/10.3390/biomedicines4030013 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Denton, Nicholas L.
Chen, Chun-Yu
Scott, Thomas R.
Cripe, Timothy P.
Tumor-Associated Macrophages in Oncolytic Virotherapy: Friend or Foe?
title Tumor-Associated Macrophages in Oncolytic Virotherapy: Friend or Foe?
title_full Tumor-Associated Macrophages in Oncolytic Virotherapy: Friend or Foe?
title_fullStr Tumor-Associated Macrophages in Oncolytic Virotherapy: Friend or Foe?
title_full_unstemmed Tumor-Associated Macrophages in Oncolytic Virotherapy: Friend or Foe?
title_short Tumor-Associated Macrophages in Oncolytic Virotherapy: Friend or Foe?
title_sort tumor-associated macrophages in oncolytic virotherapy: friend or foe?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344259/
https://www.ncbi.nlm.nih.gov/pubmed/28536380
http://dx.doi.org/10.3390/biomedicines4030013
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