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Tumor-Associated Macrophages in Oncolytic Virotherapy: Friend or Foe?
Cancer therapy remains a challenge due to toxicity limitations of chemotherapy and radiation therapy. Oncolytic viruses that selectively replicate and destroy cancer cells are of increasing interest. In addition to direct cell lysis, these vectors stimulate an anti-tumor immune response. A key regul...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344259/ https://www.ncbi.nlm.nih.gov/pubmed/28536380 http://dx.doi.org/10.3390/biomedicines4030013 |
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author | Denton, Nicholas L. Chen, Chun-Yu Scott, Thomas R. Cripe, Timothy P. |
author_facet | Denton, Nicholas L. Chen, Chun-Yu Scott, Thomas R. Cripe, Timothy P. |
author_sort | Denton, Nicholas L. |
collection | PubMed |
description | Cancer therapy remains a challenge due to toxicity limitations of chemotherapy and radiation therapy. Oncolytic viruses that selectively replicate and destroy cancer cells are of increasing interest. In addition to direct cell lysis, these vectors stimulate an anti-tumor immune response. A key regulator of tumor immunity is the tumor-associated macrophage population. Macrophages can either support oncolytic virus therapy through pro-inflammatory stimulation of the anti-tumor response at the cost of hindering direct oncolysis or through immunosuppressive protection of virus replication at the cost of hindering the anti-tumor immune response. Despite similarities in macrophage interaction between adult and pediatric tumors and the abundance of research supporting macrophage modulation in adult tumors, there are few studies investigating macrophage modulation in pediatric cancers or modulation of immunotherapy. We review the current state of knowledge regarding macrophages in cancers and their influence on oncolytic virotherapy. |
format | Online Article Text |
id | pubmed-5344259 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-53442592017-05-23 Tumor-Associated Macrophages in Oncolytic Virotherapy: Friend or Foe? Denton, Nicholas L. Chen, Chun-Yu Scott, Thomas R. Cripe, Timothy P. Biomedicines Review Cancer therapy remains a challenge due to toxicity limitations of chemotherapy and radiation therapy. Oncolytic viruses that selectively replicate and destroy cancer cells are of increasing interest. In addition to direct cell lysis, these vectors stimulate an anti-tumor immune response. A key regulator of tumor immunity is the tumor-associated macrophage population. Macrophages can either support oncolytic virus therapy through pro-inflammatory stimulation of the anti-tumor response at the cost of hindering direct oncolysis or through immunosuppressive protection of virus replication at the cost of hindering the anti-tumor immune response. Despite similarities in macrophage interaction between adult and pediatric tumors and the abundance of research supporting macrophage modulation in adult tumors, there are few studies investigating macrophage modulation in pediatric cancers or modulation of immunotherapy. We review the current state of knowledge regarding macrophages in cancers and their influence on oncolytic virotherapy. MDPI 2016-07-07 /pmc/articles/PMC5344259/ /pubmed/28536380 http://dx.doi.org/10.3390/biomedicines4030013 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Denton, Nicholas L. Chen, Chun-Yu Scott, Thomas R. Cripe, Timothy P. Tumor-Associated Macrophages in Oncolytic Virotherapy: Friend or Foe? |
title | Tumor-Associated Macrophages in Oncolytic Virotherapy: Friend or Foe? |
title_full | Tumor-Associated Macrophages in Oncolytic Virotherapy: Friend or Foe? |
title_fullStr | Tumor-Associated Macrophages in Oncolytic Virotherapy: Friend or Foe? |
title_full_unstemmed | Tumor-Associated Macrophages in Oncolytic Virotherapy: Friend or Foe? |
title_short | Tumor-Associated Macrophages in Oncolytic Virotherapy: Friend or Foe? |
title_sort | tumor-associated macrophages in oncolytic virotherapy: friend or foe? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344259/ https://www.ncbi.nlm.nih.gov/pubmed/28536380 http://dx.doi.org/10.3390/biomedicines4030013 |
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