Exosomes confer chemoresistance to pancreatic cancer cells by promoting ROS detoxification and miR-155-mediated suppression of key gemcitabine-metabolising enzyme, DCK

BACKGROUND: Chemoresistance is a significant clinical problem in pancreatic cancer (PC) and underlying molecular mechanisms still remain to be completely understood. Here we report a novel exosome-mediated mechanism of drug-induced acquired chemoresistance in PC cells. METHODS: Differential ultracen...

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Detalles Bibliográficos
Autores principales: Patel, Girijesh Kumar, Khan, Mohammad Aslam, Bhardwaj, Arun, Srivastava, Sanjeev K, Zubair, Haseeb, Patton, Mary C, Singh, Seema, Khushman, Moh'd, Singh, Ajay P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344296/
https://www.ncbi.nlm.nih.gov/pubmed/28152544
http://dx.doi.org/10.1038/bjc.2017.18

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