Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model

Defective lysosomal acidification contributes to virtually all lysosomal storage disorders (LSDs) and to common neurodegenerative diseases like Alzheimer's and Parkinson's. Despite its fundamental importance, the mechanism(s) underlying this defect remains unclear. The v-ATPase, a multisub...

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Detalles Bibliográficos
Autores principales: Bagh, Maria B., Peng, Shiyong, Chandra, Goutam, Zhang, Zhongjian, Singh, Satya P., Pattabiraman, Nagarajan, Liu, Aiyi, Mukherjee, Anil B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344305/
https://www.ncbi.nlm.nih.gov/pubmed/28266544
http://dx.doi.org/10.1038/ncomms14612

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