Activation of G protein-coupled estrogen receptor 1 induces coronary artery relaxation via Epac/Rap1-mediated inhibition of RhoA/Rho kinase pathway in parallel with PKA

Previously, we reported that cAMP/PKA signaling is involved in GPER-mediated coronary relaxation by activating MLCP via inhibition of RhoA pathway. In the current study, we tested the hypothesis that activation of GPER induces coronary artery relaxation via inhibition of RhoA/Rho kinase pathway by c...

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Detalles Bibliográficos
Autores principales: Yu, Xuan, Zhang, Qiao, Zhao, Yan, Schwarz, Benjamin J., Stallone, John N., Heaps, Cristine L., Han, Guichun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344336/
https://www.ncbi.nlm.nih.gov/pubmed/28278256
http://dx.doi.org/10.1371/journal.pone.0173085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344336/
https://www.ncbi.nlm.nih.gov/pubmed/28278256
http://dx.doi.org/10.1371/journal.pone.0173085

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