Directed evolution of a soluble human DR3 receptor for the inhibition of TL1A induced cytokine secretion

TNF-like 1A (TL1A) is a cytokine belonging to the TNF superfamily that promotes inflammation in autoimmune diseases. Inhibiting the interaction of TL1A with the endogenous death-domain receptor 3 (DR3) offers a therapeutic approach for treating TL1A-induced autoimmune diseases. Here, we generated im...

Descripción completa

Detalles Bibliográficos
Autores principales: Levin, Itay, Zaretsky, Marianna, Aharoni, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344418/
https://www.ncbi.nlm.nih.gov/pubmed/28278297
http://dx.doi.org/10.1371/journal.pone.0173460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344418/
https://www.ncbi.nlm.nih.gov/pubmed/28278297
http://dx.doi.org/10.1371/journal.pone.0173460

Ejemplares similares