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Directed evolution of a soluble human DR3 receptor for the inhibition of TL1A induced cytokine secretion

TNF-like 1A (TL1A) is a cytokine belonging to the TNF superfamily that promotes inflammation in autoimmune diseases. Inhibiting the interaction of TL1A with the endogenous death-domain receptor 3 (DR3) offers a therapeutic approach for treating TL1A-induced autoimmune diseases. Here, we generated im...

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Detalles Bibliográficos
Autores principales:	Levin, Itay, Zaretsky, Marianna, Aharoni, Amir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344418/ https://www.ncbi.nlm.nih.gov/pubmed/28278297 http://dx.doi.org/10.1371/journal.pone.0173460

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