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Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice
Sarcolipin (SLN) and phospholamban (PLN) are two small proteins that regulate the sarco(endo)plasmic reticulum Ca(2+)-ATPase pumps. In a recent study, we discovered that Pln overexpression (Pln(OE)) in slow-twitch type I skeletal muscle fibers drastically impaired SERCA function and caused a centron...
Autores principales: | Fajardo, Val A., Gamu, Daniel, Mitchell, Andrew, Bloemberg, Darin, Bombardier, Eric, Chambers, Paige J., Bellissimo, Catherine, Quadrilatero, Joe, Tupling, A. Russell |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344511/ https://www.ncbi.nlm.nih.gov/pubmed/28278204 http://dx.doi.org/10.1371/journal.pone.0173708 |
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