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Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study

OBJECTIVE: The objective of the study was to analyse placental hormone profiles in twin pregnancies to determine if they could be used to predict preterm birth. STUDY DESIGN: Progesterone, estradiol, estriol and corticotropin-releasing hormone were measured using competitive immunoassay and radioimm...

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Autores principales: Lim, Hui, Powell, Sioned, Mcnamara, Helen C., Howie, A. Forbes, Doust, Ann, Bowman, Maria E., Smith, Roger, Norman, Jane E., Stock, Sarah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344513/
https://www.ncbi.nlm.nih.gov/pubmed/28278220
http://dx.doi.org/10.1371/journal.pone.0173732
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author Lim, Hui
Powell, Sioned
Mcnamara, Helen C.
Howie, A. Forbes
Doust, Ann
Bowman, Maria E.
Smith, Roger
Norman, Jane E.
Stock, Sarah J.
author_facet Lim, Hui
Powell, Sioned
Mcnamara, Helen C.
Howie, A. Forbes
Doust, Ann
Bowman, Maria E.
Smith, Roger
Norman, Jane E.
Stock, Sarah J.
author_sort Lim, Hui
collection PubMed
description OBJECTIVE: The objective of the study was to analyse placental hormone profiles in twin pregnancies to determine if they could be used to predict preterm birth. STUDY DESIGN: Progesterone, estradiol, estriol and corticotropin-releasing hormone were measured using competitive immunoassay and radioimmunoassay in serum and saliva samples of 98 women with twin pregnancies,at 3 or more gestational timepoints. Hormone profiles throughout gestation were compared between very preterm (<34 weeks; n = 8), preterm (<37 weeks; n = 40) and term (37+ weeks; n = 50) deliveries. RESULTS: No significant differences were found between preterm and term deliveries in either absolute hormone concentrations or ratios. Estimated hormone concentrations and ratios at 26 weeks did not appear to predict preterm delivery. Salivary and serum hormone concentrations were generally poorly correlated. CONCLUSION: Our results suggest that serial progesterone, estradiol, estriol and corticotropin-releasing hormone measurements in saliva and serum are not robust biomarkers for preterm birth in twin pregnancies.
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spelling pubmed-53445132017-03-29 Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study Lim, Hui Powell, Sioned Mcnamara, Helen C. Howie, A. Forbes Doust, Ann Bowman, Maria E. Smith, Roger Norman, Jane E. Stock, Sarah J. PLoS One Research Article OBJECTIVE: The objective of the study was to analyse placental hormone profiles in twin pregnancies to determine if they could be used to predict preterm birth. STUDY DESIGN: Progesterone, estradiol, estriol and corticotropin-releasing hormone were measured using competitive immunoassay and radioimmunoassay in serum and saliva samples of 98 women with twin pregnancies,at 3 or more gestational timepoints. Hormone profiles throughout gestation were compared between very preterm (<34 weeks; n = 8), preterm (<37 weeks; n = 40) and term (37+ weeks; n = 50) deliveries. RESULTS: No significant differences were found between preterm and term deliveries in either absolute hormone concentrations or ratios. Estimated hormone concentrations and ratios at 26 weeks did not appear to predict preterm delivery. Salivary and serum hormone concentrations were generally poorly correlated. CONCLUSION: Our results suggest that serial progesterone, estradiol, estriol and corticotropin-releasing hormone measurements in saliva and serum are not robust biomarkers for preterm birth in twin pregnancies. Public Library of Science 2017-03-09 /pmc/articles/PMC5344513/ /pubmed/28278220 http://dx.doi.org/10.1371/journal.pone.0173732 Text en © 2017 Lim et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lim, Hui
Powell, Sioned
Mcnamara, Helen C.
Howie, A. Forbes
Doust, Ann
Bowman, Maria E.
Smith, Roger
Norman, Jane E.
Stock, Sarah J.
Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study
title Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study
title_full Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study
title_fullStr Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study
title_full_unstemmed Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study
title_short Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study
title_sort placental hormone profiles as predictors of preterm birth in twin pregnancy: a prospective cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344513/
https://www.ncbi.nlm.nih.gov/pubmed/28278220
http://dx.doi.org/10.1371/journal.pone.0173732
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