Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells

Oxidative stress activates the cellular kinase HRI, which then phosphorylates eIF2α, resulting in stalled translation initiation and the formation of stress granules (SGs). SG assembly redirects cellular translation to stress response mRNAs and inhibits cap-dependent viral RNA translation. Flaviviru...

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Detalles Bibliográficos
Autores principales: Basu, Mausumi, Courtney, Sean C., Brinton, Margo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344523/
https://www.ncbi.nlm.nih.gov/pubmed/28241074
http://dx.doi.org/10.1371/journal.ppat.1006240

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