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First-Row Transition Metal Doping in Calcium Phosphate Bioceramics: A Detailed Crystallographic Study
Doped calcium phosphate bioceramics are promising materials for bone repair surgery because of their chemical resemblance to the mineral constituent of bone. Among these materials, BCP samples composed of hydroxyapatite (Ca(10)(PO(4))(6)(OH)(2)) and β-TCP (Ca(3)(PO(4))(2)) present a mineral analogy...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344588/ https://www.ncbi.nlm.nih.gov/pubmed/28772452 http://dx.doi.org/10.3390/ma10010092 |
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author | Renaudin, Guillaume Gomes, Sandrine Nedelec, Jean-Marie |
author_facet | Renaudin, Guillaume Gomes, Sandrine Nedelec, Jean-Marie |
author_sort | Renaudin, Guillaume |
collection | PubMed |
description | Doped calcium phosphate bioceramics are promising materials for bone repair surgery because of their chemical resemblance to the mineral constituent of bone. Among these materials, BCP samples composed of hydroxyapatite (Ca(10)(PO(4))(6)(OH)(2)) and β-TCP (Ca(3)(PO(4))(2)) present a mineral analogy with the nano-multi-substituted hydroxyapatite bio-mineral part of bones. At the same time, doping can be used to tune the biological properties of these ceramics. This paper presents a general overview of the doping mechanisms of BCP samples using cations from the first-row transition metals (from manganese to zinc), with respect to the applied sintering temperature. The results enable the preparation of doped synthetic BCP that can be used to tailor biological properties, in particular by tuning the release amounts upon interaction with biological fluids. Intermediate sintering temperatures stabilize the doping elements in the more soluble β-TCP phase, which favors quick and easy release upon integration in the biological environment, whereas higher sintering temperatures locate the doping elements in the weakly soluble HAp phase, enabling a slow and continuous supply of the bio-inspired properties. An interstitial doping mechanism in the HAp hexagonal channel is observed for the six investigated cations (Mn(2+), Fe(3+), Co(2+), Ni(2+), Cu(2+) and Zn(2+)) with specific characteristics involving a shift away from the center of the hexagonal channel (Fe(3+), Co(2+)), cationic oxidation (Mn(3+), Co(3+)), and also cationic reduction (Cu(+)). The complete crystallochemical study highlights a complex HAp doping mechanism, mainly realized by an interstitial process combined with calcium substitution for the larger cations of the series leading to potentially calcium deficient HAp. |
format | Online Article Text |
id | pubmed-5344588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-53445882017-07-28 First-Row Transition Metal Doping in Calcium Phosphate Bioceramics: A Detailed Crystallographic Study Renaudin, Guillaume Gomes, Sandrine Nedelec, Jean-Marie Materials (Basel) Article Doped calcium phosphate bioceramics are promising materials for bone repair surgery because of their chemical resemblance to the mineral constituent of bone. Among these materials, BCP samples composed of hydroxyapatite (Ca(10)(PO(4))(6)(OH)(2)) and β-TCP (Ca(3)(PO(4))(2)) present a mineral analogy with the nano-multi-substituted hydroxyapatite bio-mineral part of bones. At the same time, doping can be used to tune the biological properties of these ceramics. This paper presents a general overview of the doping mechanisms of BCP samples using cations from the first-row transition metals (from manganese to zinc), with respect to the applied sintering temperature. The results enable the preparation of doped synthetic BCP that can be used to tailor biological properties, in particular by tuning the release amounts upon interaction with biological fluids. Intermediate sintering temperatures stabilize the doping elements in the more soluble β-TCP phase, which favors quick and easy release upon integration in the biological environment, whereas higher sintering temperatures locate the doping elements in the weakly soluble HAp phase, enabling a slow and continuous supply of the bio-inspired properties. An interstitial doping mechanism in the HAp hexagonal channel is observed for the six investigated cations (Mn(2+), Fe(3+), Co(2+), Ni(2+), Cu(2+) and Zn(2+)) with specific characteristics involving a shift away from the center of the hexagonal channel (Fe(3+), Co(2+)), cationic oxidation (Mn(3+), Co(3+)), and also cationic reduction (Cu(+)). The complete crystallochemical study highlights a complex HAp doping mechanism, mainly realized by an interstitial process combined with calcium substitution for the larger cations of the series leading to potentially calcium deficient HAp. MDPI 2017-01-23 /pmc/articles/PMC5344588/ /pubmed/28772452 http://dx.doi.org/10.3390/ma10010092 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Renaudin, Guillaume Gomes, Sandrine Nedelec, Jean-Marie First-Row Transition Metal Doping in Calcium Phosphate Bioceramics: A Detailed Crystallographic Study |
title | First-Row Transition Metal Doping in Calcium Phosphate Bioceramics: A Detailed Crystallographic Study |
title_full | First-Row Transition Metal Doping in Calcium Phosphate Bioceramics: A Detailed Crystallographic Study |
title_fullStr | First-Row Transition Metal Doping in Calcium Phosphate Bioceramics: A Detailed Crystallographic Study |
title_full_unstemmed | First-Row Transition Metal Doping in Calcium Phosphate Bioceramics: A Detailed Crystallographic Study |
title_short | First-Row Transition Metal Doping in Calcium Phosphate Bioceramics: A Detailed Crystallographic Study |
title_sort | first-row transition metal doping in calcium phosphate bioceramics: a detailed crystallographic study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344588/ https://www.ncbi.nlm.nih.gov/pubmed/28772452 http://dx.doi.org/10.3390/ma10010092 |
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