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First-Row Transition Metal Doping in Calcium Phosphate Bioceramics: A Detailed Crystallographic Study

Doped calcium phosphate bioceramics are promising materials for bone repair surgery because of their chemical resemblance to the mineral constituent of bone. Among these materials, BCP samples composed of hydroxyapatite (Ca(10)(PO(4))(6)(OH)(2)) and β-TCP (Ca(3)(PO(4))(2)) present a mineral analogy...

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Autores principales: Renaudin, Guillaume, Gomes, Sandrine, Nedelec, Jean-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344588/
https://www.ncbi.nlm.nih.gov/pubmed/28772452
http://dx.doi.org/10.3390/ma10010092
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author Renaudin, Guillaume
Gomes, Sandrine
Nedelec, Jean-Marie
author_facet Renaudin, Guillaume
Gomes, Sandrine
Nedelec, Jean-Marie
author_sort Renaudin, Guillaume
collection PubMed
description Doped calcium phosphate bioceramics are promising materials for bone repair surgery because of their chemical resemblance to the mineral constituent of bone. Among these materials, BCP samples composed of hydroxyapatite (Ca(10)(PO(4))(6)(OH)(2)) and β-TCP (Ca(3)(PO(4))(2)) present a mineral analogy with the nano-multi-substituted hydroxyapatite bio-mineral part of bones. At the same time, doping can be used to tune the biological properties of these ceramics. This paper presents a general overview of the doping mechanisms of BCP samples using cations from the first-row transition metals (from manganese to zinc), with respect to the applied sintering temperature. The results enable the preparation of doped synthetic BCP that can be used to tailor biological properties, in particular by tuning the release amounts upon interaction with biological fluids. Intermediate sintering temperatures stabilize the doping elements in the more soluble β-TCP phase, which favors quick and easy release upon integration in the biological environment, whereas higher sintering temperatures locate the doping elements in the weakly soluble HAp phase, enabling a slow and continuous supply of the bio-inspired properties. An interstitial doping mechanism in the HAp hexagonal channel is observed for the six investigated cations (Mn(2+), Fe(3+), Co(2+), Ni(2+), Cu(2+) and Zn(2+)) with specific characteristics involving a shift away from the center of the hexagonal channel (Fe(3+), Co(2+)), cationic oxidation (Mn(3+), Co(3+)), and also cationic reduction (Cu(+)). The complete crystallochemical study highlights a complex HAp doping mechanism, mainly realized by an interstitial process combined with calcium substitution for the larger cations of the series leading to potentially calcium deficient HAp.
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spelling pubmed-53445882017-07-28 First-Row Transition Metal Doping in Calcium Phosphate Bioceramics: A Detailed Crystallographic Study Renaudin, Guillaume Gomes, Sandrine Nedelec, Jean-Marie Materials (Basel) Article Doped calcium phosphate bioceramics are promising materials for bone repair surgery because of their chemical resemblance to the mineral constituent of bone. Among these materials, BCP samples composed of hydroxyapatite (Ca(10)(PO(4))(6)(OH)(2)) and β-TCP (Ca(3)(PO(4))(2)) present a mineral analogy with the nano-multi-substituted hydroxyapatite bio-mineral part of bones. At the same time, doping can be used to tune the biological properties of these ceramics. This paper presents a general overview of the doping mechanisms of BCP samples using cations from the first-row transition metals (from manganese to zinc), with respect to the applied sintering temperature. The results enable the preparation of doped synthetic BCP that can be used to tailor biological properties, in particular by tuning the release amounts upon interaction with biological fluids. Intermediate sintering temperatures stabilize the doping elements in the more soluble β-TCP phase, which favors quick and easy release upon integration in the biological environment, whereas higher sintering temperatures locate the doping elements in the weakly soluble HAp phase, enabling a slow and continuous supply of the bio-inspired properties. An interstitial doping mechanism in the HAp hexagonal channel is observed for the six investigated cations (Mn(2+), Fe(3+), Co(2+), Ni(2+), Cu(2+) and Zn(2+)) with specific characteristics involving a shift away from the center of the hexagonal channel (Fe(3+), Co(2+)), cationic oxidation (Mn(3+), Co(3+)), and also cationic reduction (Cu(+)). The complete crystallochemical study highlights a complex HAp doping mechanism, mainly realized by an interstitial process combined with calcium substitution for the larger cations of the series leading to potentially calcium deficient HAp. MDPI 2017-01-23 /pmc/articles/PMC5344588/ /pubmed/28772452 http://dx.doi.org/10.3390/ma10010092 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Renaudin, Guillaume
Gomes, Sandrine
Nedelec, Jean-Marie
First-Row Transition Metal Doping in Calcium Phosphate Bioceramics: A Detailed Crystallographic Study
title First-Row Transition Metal Doping in Calcium Phosphate Bioceramics: A Detailed Crystallographic Study
title_full First-Row Transition Metal Doping in Calcium Phosphate Bioceramics: A Detailed Crystallographic Study
title_fullStr First-Row Transition Metal Doping in Calcium Phosphate Bioceramics: A Detailed Crystallographic Study
title_full_unstemmed First-Row Transition Metal Doping in Calcium Phosphate Bioceramics: A Detailed Crystallographic Study
title_short First-Row Transition Metal Doping in Calcium Phosphate Bioceramics: A Detailed Crystallographic Study
title_sort first-row transition metal doping in calcium phosphate bioceramics: a detailed crystallographic study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344588/
https://www.ncbi.nlm.nih.gov/pubmed/28772452
http://dx.doi.org/10.3390/ma10010092
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