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The Effect of Bisphasic Calcium Phosphate Block Bone Graft Materials with Polysaccharides on Bone Regeneration

In this study, bisphasic calcium phosphate (BCP) and two types of polysaccharide, carboxymethyl cellulose (CMC) and hyaluronic acid (HyA), were used to fabricate composite block bone grafts, and their physical and biological features and performances were compared and evaluated in vitro and in vivo....

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Autores principales: Yoo, Hyun-Sang, Bae, Ji-Hyeon, Kim, Se-Eun, Bae, Eun-Bin, Kim, So-Yeun, Choi, Kyung-Hee, Moon, Keum-Ok, Jeong, Chang-Mo, Huh, Jung-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344594/
https://www.ncbi.nlm.nih.gov/pubmed/28772381
http://dx.doi.org/10.3390/ma10010017
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author Yoo, Hyun-Sang
Bae, Ji-Hyeon
Kim, Se-Eun
Bae, Eun-Bin
Kim, So-Yeun
Choi, Kyung-Hee
Moon, Keum-Ok
Jeong, Chang-Mo
Huh, Jung-Bo
author_facet Yoo, Hyun-Sang
Bae, Ji-Hyeon
Kim, Se-Eun
Bae, Eun-Bin
Kim, So-Yeun
Choi, Kyung-Hee
Moon, Keum-Ok
Jeong, Chang-Mo
Huh, Jung-Bo
author_sort Yoo, Hyun-Sang
collection PubMed
description In this study, bisphasic calcium phosphate (BCP) and two types of polysaccharide, carboxymethyl cellulose (CMC) and hyaluronic acid (HyA), were used to fabricate composite block bone grafts, and their physical and biological features and performances were compared and evaluated in vitro and in vivo. Specimens of the following were prepared as 6 mm diameter, 2 mm thick discs; BPC mixed with CMC (the BCP/CMC group), BCP mixed with crosslinked CMC (the BCP/c-CMC group) and BCP mixed with HyA (the BCP/HyA group) and a control group (specimens were prepared using particle type BCP). A scanning electron microscope study, a compressive strength analysis, and a cytotoxicity assessment were conducted. Graft materials were implanted in each of four circular defects of 6 mm diameter in calvarial bone in seven rabbits. Animals were sacrificed after four weeks for micro-CT and histomorphometric analyses, and the findings obtained were used to calculate new bone volumes (mm(3)) and area percentages (%). It was found that these two values were significantly higher in the BCP/c-CMC group than in the other three groups (p < 0.05). Within the limitations of this study, BCP composite block bone graft material incorporating crosslinked CMC has potential utility when bone augmentation is needed.
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spelling pubmed-53445942017-07-28 The Effect of Bisphasic Calcium Phosphate Block Bone Graft Materials with Polysaccharides on Bone Regeneration Yoo, Hyun-Sang Bae, Ji-Hyeon Kim, Se-Eun Bae, Eun-Bin Kim, So-Yeun Choi, Kyung-Hee Moon, Keum-Ok Jeong, Chang-Mo Huh, Jung-Bo Materials (Basel) Article In this study, bisphasic calcium phosphate (BCP) and two types of polysaccharide, carboxymethyl cellulose (CMC) and hyaluronic acid (HyA), were used to fabricate composite block bone grafts, and their physical and biological features and performances were compared and evaluated in vitro and in vivo. Specimens of the following were prepared as 6 mm diameter, 2 mm thick discs; BPC mixed with CMC (the BCP/CMC group), BCP mixed with crosslinked CMC (the BCP/c-CMC group) and BCP mixed with HyA (the BCP/HyA group) and a control group (specimens were prepared using particle type BCP). A scanning electron microscope study, a compressive strength analysis, and a cytotoxicity assessment were conducted. Graft materials were implanted in each of four circular defects of 6 mm diameter in calvarial bone in seven rabbits. Animals were sacrificed after four weeks for micro-CT and histomorphometric analyses, and the findings obtained were used to calculate new bone volumes (mm(3)) and area percentages (%). It was found that these two values were significantly higher in the BCP/c-CMC group than in the other three groups (p < 0.05). Within the limitations of this study, BCP composite block bone graft material incorporating crosslinked CMC has potential utility when bone augmentation is needed. MDPI 2017-01-01 /pmc/articles/PMC5344594/ /pubmed/28772381 http://dx.doi.org/10.3390/ma10010017 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yoo, Hyun-Sang
Bae, Ji-Hyeon
Kim, Se-Eun
Bae, Eun-Bin
Kim, So-Yeun
Choi, Kyung-Hee
Moon, Keum-Ok
Jeong, Chang-Mo
Huh, Jung-Bo
The Effect of Bisphasic Calcium Phosphate Block Bone Graft Materials with Polysaccharides on Bone Regeneration
title The Effect of Bisphasic Calcium Phosphate Block Bone Graft Materials with Polysaccharides on Bone Regeneration
title_full The Effect of Bisphasic Calcium Phosphate Block Bone Graft Materials with Polysaccharides on Bone Regeneration
title_fullStr The Effect of Bisphasic Calcium Phosphate Block Bone Graft Materials with Polysaccharides on Bone Regeneration
title_full_unstemmed The Effect of Bisphasic Calcium Phosphate Block Bone Graft Materials with Polysaccharides on Bone Regeneration
title_short The Effect of Bisphasic Calcium Phosphate Block Bone Graft Materials with Polysaccharides on Bone Regeneration
title_sort effect of bisphasic calcium phosphate block bone graft materials with polysaccharides on bone regeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344594/
https://www.ncbi.nlm.nih.gov/pubmed/28772381
http://dx.doi.org/10.3390/ma10010017
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