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BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats

Assessing BACE1 (β-site APP cleaving enzyme 1) knockout mice for general health and neurological function may be useful in predicting risks associated with prolonged pharmacological BACE1 inhibition, a treatment approach currently being developed for Alzheimer’s disease. To determine whether BACE1 d...

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Detalles Bibliográficos
Autores principales:	Weber, Martin, Wu, Tiffany, Meilandt, William J., Dominguez, Sara L., Solanoy, Hilda O., Maloney, Janice A., Ngu, Hai, Baca, Miriam, Kung, Chung, Lima, Lisa, Earr, Timothy K., Fleck, Daniel, Shields, Shannon D., Forrest, William F., Foreman, Oded, Warming, Søren, Watts, Ryan J., Scearce-Levie, Kimberly
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345047/ https://www.ncbi.nlm.nih.gov/pubmed/28281673 http://dx.doi.org/10.1038/srep44249

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