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A GCSFR/CSF3R zebrafish mutant models the persistent basal neutrophil deficiency of severe congenital neutropenia

Granulocyte colony-stimulating factor (GCSF) and its receptor (GCSFR), also known as CSF3 and CSF3R, are required to maintain normal neutrophil numbers during basal and emergency granulopoiesis in humans, mice and zebrafish. Previous studies identified two zebrafish CSF3 ligands and a single CSF3 re...

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Detalles Bibliográficos
Autores principales:	Pazhakh, Vahid, Clark, Sharon, Keightley, M. Cristina, Lieschke, Graham J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345067/ https://www.ncbi.nlm.nih.gov/pubmed/28281657 http://dx.doi.org/10.1038/srep44455

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