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Short-course rapamycin treatment enables engraftment of immunogenic gene-engineered bone marrow under low-dose irradiation to permit long-term immunological tolerance

BACKGROUND: Application of genetically modified hematopoietic stem cells is increasingly mooted as a clinically relevant approach to protein replacement therapy, immune tolerance induction or conditions where both outcomes may be helpful. Hematopoietic stem and progenitor cell (HSPC)-mediated gene t...

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Detalles Bibliográficos
Autores principales:	Bhatt, Kunal H., Rudraraju, Rajeev, Brooks, Jeremy F., Jung, Ji-Won, Galea, Ryan, Wells, James W., Steptoe, Raymond J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345164/ https://www.ncbi.nlm.nih.gov/pubmed/28279220 http://dx.doi.org/10.1186/s13287-017-0508-3

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