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Influence of nonsteroidal anti-inflammatory drugs on aspirin’s antiplatelet effects and suggestion of the most suitable time for administration of both agents without resulting in interaction

BACKGROUND: Low-dose aspirin irreversibly inhibits platelet cyclooxygenase-1 (COX-1) and suppresses platelet aggregation. It is effective for secondary prevention of cardiovascular events. Because nonsteroidal anti-inflammatory drugs (NSAIDs) reversibly bind with COX-1, the antiplatelet effects of a...

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Detalles Bibliográficos
Autores principales:	Shibata, Kenta, Akagi, Yuuki, Nozawa, Naofumi, Shimomura, Hitoshi, Aoyama, Takao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345232/ https://www.ncbi.nlm.nih.gov/pubmed/28293429 http://dx.doi.org/10.1186/s40780-017-0078-7

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