Hepatitis C virus NS3 protein enhances hepatocellular carcinoma cell invasion by promoting PPM1A ubiquitination and degradation

BACKGROUND: Growing evidence suggests that hepatitis C virus (HCV) contributes to hepatocellular carcinoma (HCC) by directly modulating oncogenic signaling pathways. Protein phosphatase magnesium-dependent 1A (PPM1A) has recently emerged as an important tumor suppressor as it can block a range of tu...

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Detalles Bibliográficos
Autores principales: Zhou, Yali, Zhao, Yan, Gao, Yaoying, Hu, Wenjun, Qu, Yan, Lou, Ning, Zhu, Ying, Zhang, Xiaoping, Yang, Hongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345236/
https://www.ncbi.nlm.nih.gov/pubmed/28283039
http://dx.doi.org/10.1186/s13046-017-0510-8

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