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The epigenetic landscape of clear-cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of all kidney tumors. During the last few years, epigenetics has emerged as an important mechanism in ccRCC pathogenesis. Recent reports, involving large-scale methylation and sequencing analyses, have identified genes frequently ina...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Codon Publications
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345536/ https://www.ncbi.nlm.nih.gov/pubmed/28326264 http://dx.doi.org/10.15586/jkcvhl.2015.33 |
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author | Kluzek, Katarzyna Bluyssen, Hans A Wesoly, Joanna |
author_facet | Kluzek, Katarzyna Bluyssen, Hans A Wesoly, Joanna |
author_sort | Kluzek, Katarzyna |
collection | PubMed |
description | Clear cell renal cell carcinoma (ccRCC) is the most common subtype of all kidney tumors. During the last few years, epigenetics has emerged as an important mechanism in ccRCC pathogenesis. Recent reports, involving large-scale methylation and sequencing analyses, have identified genes frequently inactivated by promoter methylation and recurrent mutations in genes encoding chromatin regulatory proteins. Interestingly, three of detected genes (PBRM1, SETD2 and BAP1) are located on chromosome 3p, near the VHL gene, inactivated in over 80% ccRCC cases. This suggests that 3p alterations are an essential part of ccRCC pathogenesis. Moreover, most of the proteins encoded by these genes cooperate in histone H3 modifications. The aim of this review is to summarize the latest discoveries shedding light on deregulation of chromatin machinery in ccRCC. Newly described ccRCC-specific epigenetic alterations could potentially serve as novel diagnostic and prognostic biomarkers and become an object of novel therapeutic strategies. |
format | Online Article Text |
id | pubmed-5345536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Codon Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-53455362017-03-21 The epigenetic landscape of clear-cell renal cell carcinoma Kluzek, Katarzyna Bluyssen, Hans A Wesoly, Joanna J Kidney Cancer VHL Review Article Clear cell renal cell carcinoma (ccRCC) is the most common subtype of all kidney tumors. During the last few years, epigenetics has emerged as an important mechanism in ccRCC pathogenesis. Recent reports, involving large-scale methylation and sequencing analyses, have identified genes frequently inactivated by promoter methylation and recurrent mutations in genes encoding chromatin regulatory proteins. Interestingly, three of detected genes (PBRM1, SETD2 and BAP1) are located on chromosome 3p, near the VHL gene, inactivated in over 80% ccRCC cases. This suggests that 3p alterations are an essential part of ccRCC pathogenesis. Moreover, most of the proteins encoded by these genes cooperate in histone H3 modifications. The aim of this review is to summarize the latest discoveries shedding light on deregulation of chromatin machinery in ccRCC. Newly described ccRCC-specific epigenetic alterations could potentially serve as novel diagnostic and prognostic biomarkers and become an object of novel therapeutic strategies. Codon Publications 2015-05-28 /pmc/articles/PMC5345536/ /pubmed/28326264 http://dx.doi.org/10.15586/jkcvhl.2015.33 Text en Copyright © 2016 Codon Publications License: This open access article is licensed under Creative Commons Attribution 4.0 International (CC BY 4.0). http://creativecommons.org/licenses/by/4.0 |
spellingShingle | Review Article Kluzek, Katarzyna Bluyssen, Hans A Wesoly, Joanna The epigenetic landscape of clear-cell renal cell carcinoma |
title | The epigenetic landscape of clear-cell renal cell carcinoma |
title_full | The epigenetic landscape of clear-cell renal cell carcinoma |
title_fullStr | The epigenetic landscape of clear-cell renal cell carcinoma |
title_full_unstemmed | The epigenetic landscape of clear-cell renal cell carcinoma |
title_short | The epigenetic landscape of clear-cell renal cell carcinoma |
title_sort | epigenetic landscape of clear-cell renal cell carcinoma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345536/ https://www.ncbi.nlm.nih.gov/pubmed/28326264 http://dx.doi.org/10.15586/jkcvhl.2015.33 |
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