Effect of a Comprehensive Intervention on Plasma BDNF in Patients with Alzheimer’s Disease

A comprehensive intervention (CI) on patients with Alzheimer’s disease was assessed by measuring plasmabrain-derived neurotrophic factor (pBDNF) and ADAS-Cog score (ADAS-Cog(score)) before, immediately after (FU1), and 6 (FU2) and 24 months (FU3) after the CI. Baseline pBDNF was higher in patients w...

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Detalles Bibliográficos
Autores principales: Balietti, Marta, Giuli, Cinzia, Fattoretti, Patrizia, Fabbietti, Paolo, Papa, Roberta, Postacchini, Demetrio, Conti, Fiorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345639/
https://www.ncbi.nlm.nih.gov/pubmed/28222525
http://dx.doi.org/10.3233/JAD-161168
Descripción
Sumario:A comprehensive intervention (CI) on patients with Alzheimer’s disease was assessed by measuring plasmabrain-derived neurotrophic factor (pBDNF) and ADAS-Cog score (ADAS-Cog(score)) before, immediately after (FU1), and 6 (FU2) and 24 months (FU3) after the CI. Baseline pBDNF was higher in patients with moderate AD (but not mild AD) than in healthy controls. At FU1, pBDNF and ADAS-Cog(score) decreased significantly. At FU2 and FU3, patients’ cognitive status worsened and pBDNF further increased versus baseline, suggesting that CI interruption may be a stress event that prevents return to homeostasis. CI exerted positive short-term effects, but more information is needed on long-term consequences.

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